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Updated: May 22, 2026
Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns
Published on: May 12, 2019
Reversible visual evoked potential abnormalities in uremic children
Audrey-Anne Ethier1, Sarah Lippé, Aicha Mérouani
1Centre de Recherche, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada.
Insights
Children with cystinosis-related kidney failure show abnormal visual evoked potentials during dialysis. These visual processing deficits improve after a successful kidney transplant, indicating reversibility.
Area of Science:
- Nephrology
- Ophthalmology
- Neuroscience
Background:
- Cystinosis is a rare genetic disorder leading to kidney failure.
- Uremic children often experience multisystem complications, including visual impairments.
- Visual evoked potentials (VEPs) are used to assess the integrity of the visual pathway.
Abstract:
In this case study, two cystinosis-related uremic children were followed at the Department of Nephrology, University of Montreal Hospital Center Sainte-Justine. Pattern-reversal visual evoked potentials were recorded at two time points, during dialysis treatment (time 1) and after renal transplant (time 2). Data were compared with those obtained from a control group (n = 6). The P1 component was selected and analyzed as the electrophysiologic marker of interest. At time 1, P1 latency was delayed, and P1 amplitude was reduced compared with control subjects. Both responses fell within normal range after kidney transplantation. These results indicate that renal failure and dialysis are associated with abnormal visual evoked potentials in children with chronic renal failure, but such alterations of visual processing are reversible after kidney transplant.
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