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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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A heptaketide naphthaldehyde produced by a polyketide synthase from Nectria haematococca

Takayoshi Awakawa1, Takuya Kaji, Toshiyuki Wakimoto

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Bioorganic & Medicinal Chemistry Letters
|May 29, 2012
PubMed
Summary

Researchers identified the NhPKS1 gene in Nectria haematococca, responsible for producing fungal polyketides like bostrycoidin and fusarubin. This gene encodes a key enzyme that creates a crucial intermediate for their biosynthesis.

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