Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Wedges01:24

Wedges

A wedge is a simple machine that serves various purposes, such as adjusting the elevation of structural or mechanical parts, providing stability for heavy objects, and splitting a body into two parts. This versatile tool can amplify an applied force, making it easier to manipulate large or heavy objects.
Consider using a wedge to lift a heavy slab. Here, the wedge functions by converting the applied force into a much larger force directed almost perpendicular to the initial force. This...
Dynamic Equilibrium02:20

Dynamic Equilibrium

A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Impact01:30

Impact

Impact occurs when two bodies collide, leading to the application of impulsive forces between them. Analyzing impact mechanics involves considering two colliding particles moving along a line known as the line of impact, which passes through their centers and is perpendicular to the contact plane.
When particles with different initial velocities collide, they induce deformation by applying equal and opposite impulses. At the point of maximum deformation, the particles move together with...
Elastic Collisions: Case Study01:15

Elastic Collisions: Case Study

Elastic collision of a system demands conservation of both momentum and kinetic energy. To solve problems involving one-dimensional elastic collisions between two objects, the equations for conservation of momentum and conservation of internal kinetic energy can be used. For the two objects, the sum of momentum before the collision equals the total momentum after the collision. An elastic collision conserves internal kinetic energy, and so the sum of kinetic energies before the collision equals...
Elastic Collisions: Introduction01:00

Elastic Collisions: Introduction

An elastic collision is one that conserves both internal kinetic energy and momentum. Internal kinetic energy is the sum of the kinetic energies of the objects in a system. Truly elastic collisions can only be achieved with subatomic particles, such as electrons striking nuclei. Macroscopic collisions can be very nearly, but not quite, elastic, as some kinetic energy is always converted into other forms of energy such as heat transfer due to friction and sound. An example of a nearly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urological injuries in major pelvic trauma; the experience of a national major trauma centre. An eight patient case series.

Irish journal of medical science·2026
Same author

A cross-sectional exploration of the relationship between Parkinson's disease and peripheral blood immune cells in an ethnically diverse East London population.

Journal of the neurological sciences·2026
Same author

Assessing the quality of transurethral resection of bladder tumour (TURBT) operation notes in line with EAU guidelines.

Irish medical journal·2025
Same author

Enhancement of reactive oxygen species production by ultra-short electron pulses.

Royal Society open science·2024
Same author

Genetic knowledge, experience and educational needs of paediatric trainees in Ireland.

Irish medical journal·2023
Same author

Development and evaluation of pharmacist-provided teach-back medication counselling at hospital discharge.

International journal of clinical pharmacy·2023

Related Experiment Video

Updated: May 22, 2026

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump
09:04

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump

Published on: June 1, 2022

Interplay effects during Enhanced Dynamic Wedge deliveries.

M B Kakakhel1, T Kairn, J Kenny

  • 1School of Chemistry, Physics & Mechanical Engineering, Queensland University of Technology, GPO Box 2434, Brisbane, Qld 4001, Australia.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
|May 29, 2012
PubMed
Summary
This summary is machine-generated.

Enhanced Dynamic Wedge (EDW) treatments are affected by motion interplay. Tumor motion amplitude and period significantly impact dose discrepancies, especially with larger wedge angles and limited fractions.

Related Experiment Videos

Last Updated: May 22, 2026

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump
09:04

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump

Published on: June 1, 2022

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Radiotherapy Physics

Background:

  • Understanding interplay effects in Enhanced Dynamic Wedge (EDW) treatments is crucial for accurate dose delivery.
  • Tumor motion during radiotherapy can significantly alter planned dose distributions.

Purpose of the Study:

  • To experimentally investigate the interplay effects in Enhanced Dynamic Wedge (EDW) treatments.
  • To evaluate the impact of motion parameters (amplitude, period) and treatment factors (wedge angle, field size) on dose discrepancies.

Main Methods:

  • Delivered single and multiple field EDW plans to a phantom on a moving platform with varying motion parameters.
  • Investigated parallel and perpendicular motion, different wedge angles, and field sizes.
  • Delivered a 4D CT-planned lung EDW treatment to a dummy tumor over four fractions.

Main Results:

  • For parallel motion, both amplitude and period affected interplay, causing step functions and penumbral cut-offs.
  • Tumor motion amplitude was dominant for perpendicular motion.
  • Larger wedge angles showed more pronounced dose discrepancies.
  • Small field sizes (5x5 cm²) resulted in loss of wedged distribution.
  • 4D CT-planned delivery showed mixed over/under dosages with a 40% gamma pass rate (3%/1 mm DTA).

Conclusions:

  • Tumor motion amplitude and period significantly influence interplay effects in EDW treatments.
  • Limited fraction deliveries may not allow for averaging of EDW interplay effects.
  • These findings highlight the importance of considering motion management in EDW radiotherapy planning.