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Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Updated: May 22, 2026

Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates

Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates

Published on: September 26, 2013

Human adipose stem cells: current clinical applications.

Phanette Gir¹, Georgette Oni, Spencer A Brown

¹Dallas, Texas; and Lyon, France From the Department of Plastic Surgery, University of Texas Southwestern Medical Center, and the Department of Plastic Surgery, Edouard Herriot Hospital, University of Lyon.

Plastic and Reconstructive Surgery

|May 29, 2012

Summary

Adipose-derived stem cells show promise for regenerative medicine and plastic surgery. Further research and standardized protocols are needed to ensure their safe and effective use in humans.

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Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates

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Published on: September 26, 2013

Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation

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Isolation and Enrichment of Human Adipose-derived Stromal Cells for Enhanced Osteogenesis

Isolation and Enrichment of Human Adipose-derived Stromal Cells for Enhanced Osteogenesis

Published on: January 12, 2015

Area of Science:

Regenerative Medicine
Biotechnology
Cell Biology

Background:

Adipose-derived stem cells (ASCs) are multipotent cells with significant potential in regenerative medicine.
ASCs can be easily isolated from adipose tissue and expanded in vitro for differentiation into various cell types.
Current research focuses on overcoming challenges related to ASC isolation, purification, tumor growth effects, and regulatory compliance for human applications.

Purpose of the Study:

To review existing basic science evidence on ASCs.
To analyze ongoing clinical trials utilizing ASCs in plastic surgery and regenerative medicine.
To assess the current state and future directions of ASC research and application.

Main Methods:

Comprehensive literature review of published basic science studies.
Analysis of data from ongoing global clinical trials involving ASCs.
Synthesis of findings to evaluate safety, efficacy, and application disparities.

Main Results:

ASC applications show promising results in plastic surgery and diverse medical specialties.
A growing number of clinical trials worldwide are exploring ASC therapies.
Disparities exist in the methodologies and applications of ASCs across studies.

Conclusions:

ASCs hold considerable potential for therapeutic applications in regenerative medicine.
Standardized protocols and rigorous basic science research are crucial for ensuring ASC safety and efficacy.
Further large-scale, randomized clinical trials are necessary to meet U.S. Food and Drug Administration guidelines for ASC use.