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Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
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Quantitative cardiovascular magnetic resonance perfusion imaging: inter-study reproducibility.

Geraint Morton1, Roy Jogiya, Sven Plein

  • 1Division of Imaging Sciences, The Rayne Institute, King’s College London, 4th Floor Lambeth Wing, St Thomas’ Hospital, London SE1 7EH, UK. geraintmorton@gmail.com

European Heart Journal. Cardiovascular Imaging
|May 29, 2012
PubMed
Summary

Quantitative cardiovascular magnetic resonance (CMR) myocardial perfusion imaging shows reasonable inter-study reproducibility, particularly for global rest perfusion. No significant diurnal variations were detected, supporting its use in serial assessments.

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Area of Science:

  • Cardiovascular imaging
  • Medical physics
  • Physiology

Background:

  • Quantitative cardiovascular magnetic resonance (CMR) myocardial perfusion imaging is vital for serial assessments in clinical practice and trials.
  • Limited data exist on the inter-study reproducibility and diurnal variation of quantitative CMR perfusion.

Purpose of the Study:

  • To assess the inter-study reproducibility of quantitative CMR myocardial perfusion imaging.
  • To investigate the influence of diurnal variation on myocardial perfusion and left ventricular (LV) function.

Main Methods:

  • Sixteen healthy volunteers underwent high-resolution 3 T perfusion imaging three times daily.
  • Quantitative perfusion parameters (global and territorial rest/stress perfusion, myocardial perfusion reserve) were derived using Fermi deconvolution.
  • LV volumes and function were also assessed.

Main Results:

  • Inter-study reproducibility for global rest perfusion, stress perfusion, and myocardial perfusion reserve (MPR) showed moderate coefficients of variation (16.0%, 26.8%, 23.9%).
  • Territorial perfusion reproducibility was lower (CVs 27.5%–35.2%).
  • Reproducibility of LV volumes and function was excellent (CVs 4%–7.7%). No significant diurnal variations were observed for perfusion or LV parameters.

Conclusions:

  • Quantitative myocardial perfusion imaging demonstrates reasonable inter-study reproducibility, with global rest perfusion being the most reproducible metric.
  • No significant diurnal variations in myocardial perfusion or LV function were detected, suggesting reliability for serial evaluations.