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Related Experiment Videos

Altered renal function in broilers during aflatoxicosis.

R P Glahn1, K W Beers, W G Bottje

  • 1Department of Animal and Poultry Science, University of Arkansas, Fayetteville 72701.

Poultry Science
|October 1, 1990
PubMed
Summary
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Aflatoxicosis in broilers significantly reduced phosphorus excretion and plasma calcium levels. Other renal functions and acid-base balance remained largely unaffected by the toxin.

Area of Science:

  • Veterinary Medicine
  • Toxicology
  • Renal Physiology

Background:

  • Aflatoxicosis, a condition caused by aflatoxin exposure, can impact various physiological processes in poultry.
  • Understanding the specific effects of aflatoxicosis on renal function is crucial for animal health and food safety.

Purpose of the Study:

  • To investigate the impact of aflatoxicosis on acid-base balance, urine flow, glomerular filtration rate, and renal handling of electrolytes in broilers.
  • To assess the effects of aflatoxin on renal response to acute volume loads.

Main Methods:

  • Three-week-old broilers were administered aflatoxin (2 mg/kg BW/day) or a control vehicle for 10 days.
  • Renal function was analyzed on day 11, including measurements of urine flow rate (V), glomerular filtration rate (GFR), para-aminohippuric acid clearance (CPAH), plasma osmolality, and electrolyte handling (Na, K, Ca, P).

Related Experiment Videos

  • Birds were subjected to low and high infusion rates of inulin, para-aminohippuric acid, and mannitol to evaluate renal response to volume loading.

    • Main Results:

    • Aflatoxicosis significantly decreased fractional excretion of phosphorus (FEP) and plasma calcium (Ca) concentration.
    • No significant alterations were observed in other measured renal functions, including urine flow rate, GFR, CPAH, plasma osmolality, and handling of Na, K, and P.
    • Acid-base balance variables were not significantly affected by aflatoxin exposure.

    Conclusions:

    • Aflatoxicosis in broilers primarily affects phosphorus and calcium handling by the kidneys.
    • The observed decrease in FEP and plasma Ca may result from direct renal tubular damage, reduced gut calcium absorption, or altered parathyroid hormone (PTH) regulation.
    • Further research is warranted to elucidate the precise mechanisms underlying these specific renal effects of aflatoxin.