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[Biochemical monitoring of pregnancy with a hypotrophic fetus]
L Fialová1, Z Lacinová, Z Hájek
1I. ústav pro chemii lékarskou a soudní 1. lékarské fakulty Univerzity Karlovy v Praze.
The authors attempt to compare the asset of three biochemical parameters in monitoring pregnancies threatened with foetal hypotrophy. In 46 pregnant women hospitalized on account of suspected intrauterine retardation of foetal growth 121 oestrogen estimations in 24-hour urine were made, 83 examinations of serum oestriol and 101 examinations of trophoblast-specific beta-1-globulin (SP1). The authors evaluated the first collected specimen and well as repeated examinations. In women who were delivered of a hypotrophic foetus, in 72.2% there was a pathological course of urinary oestrogens and in 50% of serum oestriol and SP1. At least one of the evaluated indicators was pathological in 94% of the patients. From the results ensues that in biochemical investigations of pregnancies with a retarded intrauterine foetal growth it is useful to investigate several biochemical parameters in a parallel way. It is, however, essential to assess them dynamically as, a single examination does not provide sufficient information.
The authors attempt to compare the asset of three biochemical parameters in monitoring pregnancies threatened with foetal hypotrophy. In 46 pregnant women hospitalized on account of suspected intrauterine retardation of foetal growth 121 oestrogen estimations in 24-hour urine were made, 83 examinations of serum oestriol and 101 examinations of trophoblast-specific beta-1-globulin (SP1). The authors evaluated the first collected specimen and well as repeated examinations. In women who were delivered of a hypotrophic foetus, in 72.2% there was a pathological course of urinary oestrogens and in 50% of serum oestriol and SP1. At least one of the evaluated indicators was pathological in 94% of the patients. From the results ensues that in biochemical investigations of pregnancies with a retarded intrauterine foetal growth it is useful to investigate several biochemical parameters in a parallel way. It is, however, essential to assess them dynamically as, a single examination does not provide sufficient information.