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Localization of the Locus Coeruleus in the Mouse Brain
Published on: March 7, 2019
The human locus coeruleus 3-D stereotactic anatomy
P Fernandes1, J Regala, F Correia
1Department of Anatomy, Lisbon Faculty of Medicine, Lisbon, Portugal.
Surgical and Radiologic Anatomy : SRA
|May 29, 2012
Summary
This study precisely mapped the human locus coeruleus (LC), a key brainstem nucleus, detailing its dimensions and location for improved MRI and surgical targeting.
Area of Science:
- Neuroanatomy
- Stereotactic Anatomy
- Human Brainstem Anatomy
Background:
- The locus coeruleus (LC) is a critical nucleus in the human brainstem (HB).
- It plays a vital role as a relay for adrenergic and dopaminergic circuitry.
- Accurate localization of the LC is essential for neuroimaging and microsurgery.
Purpose of the Study:
- To investigate the stereotactic anatomy of the human locus coeruleus (LC).
- To facilitate precise localization of the LC on MRI scans.
- To aid in microsurgical procedures involving the human brainstem.
Main Methods:
- Studied 40 LC from 20 adult human brainstems (HB) of both sexes.
- Utilized melanin pigmentation for LC identification and contour definition.
- Employed cryomicrotomy with 3-D referencing and digitized imaging for precise anatomical mapping.
Main Results:
- The LC is a symmetric, elongated nucleus, averaging 14.5 mm in length and 2-2.5 mm in thickness.
- Located sub-ependymally in the superior dorsal lateral pons.
- 3-D coordinates: 3.2 mm from midline, 1.1 mm from the IV ventricle floor, and 18.5 mm from the ponto-medullary junction.
Conclusions:
- The human LC is thinner and longer than previously reported.
- Precise anatomical data provided for MRI and surgical navigation.
- No correlation found between LC dimensions and age, gender, or pons size.
