Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells12:54

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

2.3K
The methodology describes the generation of bovine monocyte-derived dendritic cells (MoDCs) and their application for the in vitro evaluation of antigenic candidates during the development of potential veterinary vaccines in...
2.3K
Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes06:09

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

23.9K
Immature dendritic cells can be selectively differentiated into tolerogenic or mature dendritic cells to regulate the balance between immunity and tolerance. This work presents a means to generate from immature monocyte derived dendritic cells (moDCs), in vitro tolerogenic and mature moDCs that differ in metabolic...
23.9K
Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

12.2K
Evaluated in syngeneic immunocompetent hosts, cancer stem cell (CSC) based dendritic cell (DC) vaccine demonstrated significantly higher antitumor immunity than traditional DC vaccines pulsed with heterogeneous bulk tumor...
12.2K
Culture of myeloid dendritic cells from bone marrow precursors06:39

Culture of myeloid dendritic cells from bone marrow precursors

23.1K
This video demonstrates the procedure for differentiating myeloid dendritic cells from mouse bone marrow. Isolation of mouse tibia and femur, and processing of bone marrow are demonstrated. Pictures demonstrating cell morphology before and after differentiation, and figures depicting cell phenotype and IL-12 production following maturation using CpG are...
23.1K
A Vaccine-Pulsed Dendritic Cell-Based In Vitro Assay to Induce Lymphocyte Proliferation05:16

A Vaccine-Pulsed Dendritic Cell-Based In Vitro Assay to Induce Lymphocyte Proliferation

579
This video demonstrates a monocyte-derived dendritic cell, MoDC-based assay to measure the immunogenicity of commercially available vaccines. MoDC assays investigate dendritic cell responses to antigens, pathogens, or treatments and can provide insights into immune responses, vaccine development, and immunotherapy...
579
Vaccinations01:51

Vaccinations

51.3K
Overview
51.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: Single-cell RNA-seq reveals diverse molecular signatures associated with Methotrexate resistance in primary central nervous system lymphoma cells.

Journal of neuro-oncology·2025
Same author

Single-cell RNA-seq reveals diverse molecular signatures associated with Methotrexate resistance in primary central nervous system lymphoma cells.

Journal of neuro-oncology·2024
Same author

Reciprocal expression of the immune response genes CXCR3 and IFI44L as module hubs are associated with patient survivals in primary central nervous system lymphoma.

International journal of clinical oncology·2023
Same author

Survival prediction based on the gene expression associated with cancer morphology and microenvironment in primary central nervous system lymphoma.

PloS one·2021
Same author

GSEA-assisted gene signatures valid for combinations of prognostic markers in PCNSL.

Scientific reports·2020
Same author

Metabolome Analysis Reveals Excessive Glycolysis via PI3K/AKT/mTOR and RAS/MAPK Signaling in Methotrexate-Resistant Primary CNS Lymphoma-Derived Cells.

Clinical cancer research : an official journal of the American Association for Cancer Research·2020

Related Experiment Video

Updated: Jan 19, 2026

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells
12:54

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Published on: May 19, 2023

2.3K

Dendritic cell vaccines.

Ryuya Yamanaka1, Koji Kajiwara

  • 1Kyoto Prefectural University of Medicine, Kyoto, Japan. ryaman@cmt.kpu-m.ac.jp

Advances in Experimental Medicine and Biology
|May 29, 2012
PubMed
Summary

Dendritic cell immunotherapy shows promise for treating malignant glioma, a type of brain tumor with a poor prognosis. This approach appears safe and effective in inducing antitumor responses, warranting further clinical trials.

Area of Science:

  • Neuro-oncology
  • Immunology
  • Biotherapy

Background:

  • Malignant glioma prognosis remains poor despite advances in brain tumor therapy.
  • Immunotherapy offers potential for high tumor-specific cytotoxicity against gliomas.
  • Dendritic cell-based immunotherapy is emerging as a potential treatment modality.

Purpose of the Study:

  • To review current literature on dendritic cell-based glioma immunotherapy.
  • To discuss the implications of dendritic cell therapy for glioma treatment.
  • To outline future directions for dendritic cell-based biotherapy.

Main Methods:

  • Overview of dendritic cells' role in immunobiology, CNS, and tumor immunology.
  • Review of clinical trial results for dendritic cell therapy in glioma.

More Related Videos

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

12.2K
A Vaccine-Pulsed Dendritic Cell-Based In Vitro Assay to Induce Lymphocyte Proliferation
05:16

A Vaccine-Pulsed Dendritic Cell-Based In Vitro Assay to Induce Lymphocyte Proliferation

579

Related Experiment Videos

Last Updated: Jan 19, 2026

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells
12:54

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Published on: May 19, 2023

2.3K
Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

12.2K
A Vaccine-Pulsed Dendritic Cell-Based In Vitro Assay to Induce Lymphocyte Proliferation
05:16

A Vaccine-Pulsed Dendritic Cell-Based In Vitro Assay to Induce Lymphocyte Proliferation

579
  • Discussion of methods for manipulating dendritic cells for vaccination.

    • Main Results:

    • Dendritic cell immunotherapy can induce an anti-glioma response.
    • This approach appears safe with no major side effects in patients with glioma.
    • Dendritic cell-based strategies show promise for inducing antitumor immune responses.

    Conclusions:

    • Dendritic cell-based immunotherapy is a promising strategy for glioma treatment.
    • Further development of dendritic cell manipulation will enhance biotherapy usefulness.
    • Randomized, controlled clinical trials are needed to determine efficacy.