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Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...

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Related Experiment Video

Updated: May 22, 2026

Quantification of Global Histone Post Translational Modifications Using Intranuclear Flow Cytometry in Isolated Mouse Brain Microglia
07:10

Quantification of Global Histone Post Translational Modifications Using Intranuclear Flow Cytometry in Isolated Mouse Brain Microglia

Published on: September 15, 2023

Epigenetics: Biology's Quantum Mechanics.

Richard A Jorgensen1

  • 1Laboratorio (LANGEBIO) Nacional de Genómica para la Biodiversidad, Centro (CINVESTAV) de Investigación y Estudios Avanzados Irapuato, Guanajuato, México.

Frontiers in Plant Science
|May 29, 2012
PubMed
Summary
This summary is machine-generated.

Modern genetics is undergoing a revolution, akin to early quantum mechanics. Integrating epigenetic and molecular views deepens our understanding of the gene and genome.

Keywords:
aperiodic crystalhistone codeparachromatinparageneticstransgenerational inheritance

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Last Updated: May 22, 2026

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Area of Science:

  • Genetics
  • Molecular Biology
  • Epigenetics
  • Quantum Mechanics

Background:

  • Modern genetics is compared to the early development of quantum mechanics in the 1920s.
  • The year 2010 is identified as the beginning of a new era in genetic research.

Purpose of the Study:

  • To explore the relationship between the molecular biological and epigenetic views of the gene.
  • To argue for the necessity of incorporating the epigenetic perspective into the classical molecular biological view.
  • To draw parallels between the evolution of genetic concepts and the development of atomic physics.

Main Methods:

  • Conceptual analysis of genetic and physics theories.
  • Comparative study of molecular and epigenetic perspectives on the gene.
  • Historical review of scientific paradigm shifts.

Main Results:

  • The classical molecular view of the gene is incomplete without epigenetics.
  • The molecular biological view is evolving to encompass epigenetic principles.
  • A parallel exists between the evolution of genetics and the shift from Newtonian to quantum mechanics.

Conclusions:

  • A paradigm shift is occurring in genetics, integrating molecular and epigenetic insights.
  • This integration promises a richer understanding of the gene and genome.
  • The evolution of genetic concepts mirrors historical scientific revolutions.