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Related Concept Videos

Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Updated: May 22, 2026

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
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A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

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Changes in immune function in asthma in the elderly.

Sameer K Mathur, Sharmilee M Nyenhuis

    Aging Health
    |May 29, 2012
    PubMed
    Summary
    This summary is machine-generated.

    This review examines how aging affects the immune system, specifically in asthma patients. It explores age-related immune changes and their impact on airway inflammation in asthma.

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    Published on: September 28, 2022

    Methodology for Sputum Induction and Laboratory Processing
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    Methodology for Sputum Induction and Laboratory Processing

    Published on: December 17, 2017

    Area of Science:

    • Immunology
    • Respiratory Medicine
    • Gerontology

    Background:

    • Asthma is characterized by allergic airway inflammation, often involving a T-helper 2 (Th2) immune response.
    • Immunosenescence describes age-related alterations in immune cell function.
    • Emerging research suggests immunosenescence may influence asthma pathophysiology.

    Purpose of the Study:

    • To review current data on immunosenescence in the context of asthma.
    • To explore how age-related immune changes affect airway inflammation in asthma.

    Main Methods:

    • Literature review of studies on asthma and aging.
    • Analysis of animal models and human subject data.
    • Synthesis of findings on immunosenescence and airway inflammation.

    Main Results:

    • Evidence indicates age-related changes in immune function are present in asthma.
    • These changes may modify the inflammatory profile of asthma.
    • Further research is needed to fully elucidate these interactions.

    Conclusions:

    • Immunosenescence is a relevant factor in understanding asthma, particularly in older adults.
    • Age-related immune alterations can impact asthma severity and treatment response.
    • Future studies should focus on the clinical implications of immunosenescence in asthma management.