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Left ventricular dyssynchrony and its effects on cardiac function in patients with newly diagnosed hypertension

Abdulkadir Kırış1, Kayıhan Karaman, Gülhanım Kırış

  • 1Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. akiris79@yahoo.com

Echocardiography (Mount Kisco, N.Y.)
|May 30, 2012
PubMed

Insights

Left ventricular (LV) systolic dyssynchrony is impaired in newly diagnosed hypertension patients. This impaired LV synchrony independently predicts reduced systolic function, highlighting its clinical significance in early hypertension management.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Hypertension Research

Background:

  • Left ventricular (LV) systolic synchrony is crucial for optimal cardiac function.
  • Hypertension is known to impair LV systolic synchrony, but its impact on LV function remains unclear.
  • Early identification of functional changes in hypertension is vital for timely intervention.

Purpose of the Study:

  • To investigate the impact of LV systolic dyssynchrony on LV function in newly diagnosed hypertensive patients.
  • To assess whether LV dyssynchrony is an independent predictor of systolic dysfunction in early hypertension.

Main Methods:

  • A cohort of 48 newly diagnosed hypertensive patients and 33 controls underwent comprehensive echocardiography.
  • Tissue synchrony imaging was used to measure the time to regional peak systolic tissue velocity (Ts) in 12 LV segments.
  • Two parameters of systolic dyssynchrony, standard deviation of Ts (Ts-SD-12) and maximal Ts difference, were computed.

Main Results:

  • Newly diagnosed hypertensive patients exhibited significantly prolonged LV dyssynchrony parameters compared to controls (Ts-SD-12: 40.2 ± 21 vs. 26.2 ± 13.4, P = 0.003).
  • Ts-SD-12 was identified as an independent predictor of impaired systolic function (β=-0.29, P = 0.008) in multivariable analysis.
  • Diastolic and global LV functions were not independently associated with Ts-SD-12.

Conclusions:

  • LV synchronization is demonstrably impaired in patients with newly diagnosed hypertension.
  • LV dyssynchrony is a significant independent predictor of systolic function in hypertensive individuals.
  • These findings underscore the importance of assessing LV synchrony in early hypertension management.
Abstract

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