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Related Experiment Video

Updated: May 22, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Green tea catechins decrease oxidative stress in surgical menopause-induced overactive bladder in a rat model.

Yung-Shun Juan1, Shu-Mien Chuang, Yi-Lun Lee

  • 1Department of Urology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

BJU International
|May 30, 2012
PubMed
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Green tea extract, epigallocatechin gallate (EGCG), prevents ovariectomy-induced overactive bladder in rats. EGCG demonstrates antioxidant, anti-fibrosis, and anti-apoptosis effects, restoring bladder function.

Area of Science:

  • Urology
  • Pharmacology
  • Cell Biology

Background:

  • Ovary hormone deficiency in post-menopausal women can lead to urological dysfunctions like overactive bladder (OAB).
  • Green tea extract contains epigallocatechin gallate (EGCG), known for its antioxidant and anti-inflammatory properties.
  • EGCG may offer protective effects against hormone deficiency-related bladder issues.

Purpose of the Study:

  • To determine if EGCG can prevent ovariectomy-induced OAB in a rat model.
  • To investigate the antioxidant, anti-apoptotic, and anti-fibrosis mechanisms of EGCG in bladder tissue.
  • To establish a dose-dependent relationship for EGCG's effects.

Main Methods:

  • 48 female rats underwent bilateral ovariectomy or sham surgery.
  • Groups received daily intraperitoneal injections of EGCG (1 µM/kg or 10 µM/kg) or saline for 6 months.

Related Experiment Videos

Last Updated: May 22, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

  • Bladder function (cystometrograms), apoptosis (TUNEL assay), and molecular markers (Western immunoblot) were assessed.

    • Main Results:

    • Ovariectomy led to increased bladder overactivity, decreased compliance, elevated apoptosis, and enhanced fibrosis.
    • EGCG treatment significantly improved bladder compliance and reduced overactivity in a dose-dependent manner.
    • EGCG administration attenuated oxidative damage, reduced inflammatory and fibrosis markers (TGF-β, collagen), and modulated apoptosis-related proteins (caspase-3, Bcl-2).

    Conclusions:

    • Ovariectomy causes significant bladder dysfunction, oxidative stress, and tissue damage.
    • EGCG effectively restores bladder function in ovariectomy-induced OAB models.
    • EGCG's therapeutic benefits are attributed to its antioxidant, anti-fibrosis, and anti-apoptotic properties.