[Cefuroxime axetil (Zinnat)--laboratory and clinical study]

Area of Science:

• Pharmacology and Microbiology

Background:

• Antibiotic resistance necessitates evaluation of existing drugs.
• Cefuroxim is a second-generation cephalosporin with known antibacterial properties.

Purpose of the Study:

• To assess the in vitro antibacterial spectrum of cefuroxim.
• To evaluate the pharmacokinetic profile of esterified cefuroxim (Zinnat).
• To determine the efficacy of prophylactic cefuroxim in biliary surgery.

Main Methods:

• In vitro susceptibility testing of cefuroxim against various bacteria.
• Serum and bile tissue concentration measurements after Zinnat administration.
• Clinical evaluation of cefuroxim prophylaxis in 20 patients undergoing biliary surgery.

Main Results:

• Cefuroxim exhibited a broad spectrum of antibacterial action in vitro.
• Oral administration of Zinnat resulted in satisfactory serum and bile cefuroxim concentrations.
• Prophylactic cefuroxim administration showed excellent outcomes in the surgical cohort.

Conclusions:

• Cefuroxim is a potent antibacterial agent with a wide spectrum of activity.
• Esterified cefuroxim (Zinnat) effectively achieves therapeutic levels for systemic and local action.
• Combined parenteral and oral cefuroxim is a highly effective prophylactic strategy in biliary surgery.