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Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...

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Related Experiment Video

Updated: May 22, 2026

In Silico Clinical Trials for Cardiovascular Disease
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In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Evaluation of a transient, simultaneous, arbitrary Lagrange-Euler based multi-physics method for simulating the

Daniel M Espino1, Duncan E T Shepherd, David W L Hukins

  • 1a School of Mechanical Engineering, University of Birmingham , Birmingham , B15 2TT , UK.

Computer Methods in Biomechanics and Biomedical Engineering
|May 30, 2012
PubMed
Summary

A new computational model simulates mitral heart valve function, calculating fluid flow and deformation simultaneously. This fluid-structure interaction model accurately predicts valve closure during systole.

Keywords:
Hertzian contactfluid–structure interactionlarge strainmitral valvemulti-physics modelling

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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

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In Silico Clinical Trials for Cardiovascular Disease
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Published on: May 27, 2022

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Area of Science:

  • Cardiovascular Science
  • Biomedical Engineering
  • Computational Fluid Dynamics

Background:

  • Accurate simulation of heart valve dynamics is crucial for understanding cardiovascular health.
  • Existing models often lack the capability for simultaneous fluid flow and structural deformation analysis.

Purpose of the Study:

  • To develop a transient multi-physics model for the mitral heart valve.
  • To enable simultaneous calculation of fluid flow and structural deformation, including systole.

Main Methods:

  • Developed a transient multi-physics model for the mitral heart valve.
  • Applied a novel contact method for simulating systole.
  • Utilized a 2D simplified geometry and a moving arbitrary Lagrange-Euler mesh for fluid-structure interaction (FSI).

Main Results:

  • The FSI model successfully simulated mitral valve closure induced by blood flow.
  • Predicted valve strains were in the range of 10-20%.
  • Model predictions showed consistency with existing literature.

Conclusions:

  • The developed model provides a robust platform for simulating mitral valve dynamics.
  • The model accurately captures fluid-structure interaction during systole.
  • Further development will enhance the model's predictive capabilities.