Related Experiment Video
Updated: May 22, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Evaluation of a transient, simultaneous, arbitrary Lagrange-Euler based multi-physics method for simulating the
Daniel M Espino1, Duncan E T Shepherd, David W L Hukins
1a School of Mechanical Engineering, University of Birmingham , Birmingham , B15 2TT , UK.
Abstract:
A transient multi-physics model of the mitral heart valve has been developed, which allows simultaneous calculation of fluid flow and structural deformation. A recently developed contact method has been applied to enable simulation of systole (the stage when blood pressure is elevated within the heart to pump blood to the body). The geometry was simplified to represent the mitral valve within the heart walls in two dimensions. Only the mitral valve undergoes deformation. A moving arbitrary Lagrange-Euler mesh is used to allow true fluid-structure interaction (FSI). The FSI model requires blood flow to induce valve closure by inducing strains in the region of 10-20%. Model predictions were found to be consistent with existing literature and will undergo further development.
Related Concept Videos
Mitral Regurgitation I: Introduction
Mitral Valve Prolapse II: Assessment and Management
Mitral Valve Prolapse I: Introduction
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Regurgitation III: Medical Management
