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Related Experiment Video

Updated: May 22, 2026

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
09:57

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index

Published on: January 2, 2012

Aberrant cortical gyrification in schizophrenia: a surface-based morphometry study.

Lena Palaniyappan1, Peter F Liddle

  • 1Division of Psychiatry, University of Nottingham, South Block, Queen's Medical Centre, Nottingham, United Kingdom. Lena.Palaniyappan@nottingham.ac.uk

Journal of Psychiatry & Neuroscience : JPN
|May 30, 2012
PubMed
Summary
This summary is machine-generated.

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Schizophrenia is linked to abnormal brain folding (gyrification), particularly in the left hemisphere. These gyrification defects may stem from disrupted interactions between brain regions, contributing to the illness.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Neuroscience

Background:

  • Schizophrenia is characterized by impaired cerebral connectivity and cortical development.
  • Early disturbances in cortical maturation can lead to widespread gyrification defects.

Purpose of the Study:

  • To investigate the anatomical distribution of gyrification defects in schizophrenia.
  • To explore the relationship between gyrification and cortical thickness.

Main Methods:

  • Automated surface-based morphometric assessment of gyrification across the entire cortex.
  • Analysis of a sample of 57 patients with schizophrenia and 41 controls.
  • Region-of-interest approach focusing on the prefrontal cortex.

Main Results:

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09:57

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  • Significant hypogyria (reduced gyrification) observed primarily in the left insula and multimodal association cortex.
  • Prefrontal hypergyria findings were not statistically significant after whole-brain correction but emerged at a lower threshold.
  • Reduced gyrification in the insula correlated with decreased cortical thickness in patients.

Conclusions:

  • Cortical gyrification disturbances in schizophrenia may result from disrupted interactions between paralimbic and multimodal association cortices.
  • These findings contribute to understanding the pathogenesis of schizophrenia.
  • Limitations include medication effects and a predominantly male sample, affecting generalizability.