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Denervation in hemiplegic muscles.

W F Brown1, R Snow

  • 1Department of Clinical Neurological Sciences, University Hospital, London, Ontario, Canada.

Stroke
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

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Denervation activity in hemiplegic muscles is common, particularly in distal muscles. Normal nerve conduction studies suggest transsynaptic degeneration, not peripheral nerve trauma, may cause this fibrillation.

Area of Science:

  • Neurology
  • Neurophysiology

Background:

  • Hemiplegic muscles often exhibit denervation activity, but its cause is debated.
  • Central nervous system lesions are implicated in muscle dysfunction.

Purpose of the Study:

  • To investigate the relationship between central lesion characteristics and denervation activity in hemiplegic muscles.
  • To differentiate between peripheral nerve trauma and central nervous system-related mechanisms for denervation.

Main Methods:

  • Somatosensory evoked potentials (SEPs) and motor conduction studies were performed on 20 hemiplegic patients.
  • Conduction across nerve roots and the brachial plexus was assessed.
  • Fibrillation activity was evaluated in affected muscles.

Main Results:

Related Experiment Videos

  • No conduction abnormalities were detected on the affected side in any patient.
  • Fibrillation was frequently observed, especially in distal and intermediate muscles.
  • The pattern of fibrillation and normal conduction studies did not support peripheral nerve trauma.

Conclusions:

  • Transsynaptic degeneration is a plausible explanation for denervation activity in hemiplegic muscles.
  • Central nervous system lesions can lead to secondary muscle changes without direct peripheral nerve injury.