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Updated: May 22, 2026
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Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis
Published on: June 2, 2022
[Autoimmune synaptic encephalitis is a disease entity on the rise]
Signe Modvig1, Christina Engel Høi-Hansen, Peter Uldall
1Neurologisk Afdeling, Glostrup Hospital, Nordre Ringvej 57, Glostrup. signemodvig@gmail.com
Ugeskrift for Laeger
|May 30, 2012
Summary
Autoimmune synaptic encephalitis (ASE) involves antibodies targeting neuronal synapses. This review covers four key ASE types, detailing their epidemiology, clinical features, and treatments for better understanding and management.
Area of Science:
- Neuroimmunology
- Neurology
Context:
- Autoimmune synaptic encephalitis (ASE) is a group of rare neurological disorders.
- These conditions are characterized by the presence of autoantibodies targeting neuronal synaptic structures.
Purpose:
- To review the epidemiology, clinical characteristics, and treatment of four major types of ASE.
- To provide a comprehensive overview of anti-N-methyl-D-aspartate receptor encephalitis, anti-α-amine-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor encephalitis, anti-gamma-aminobutyric acid receptor 1 encephalitis, and anti-leucine-rich glioma-inactivated 1 encephalitis.
Summary:
- ASE encompasses encephalitides linked to autoantibodies against neuronal synapse components.
- The review details four specific types: anti-N-methyl-D-aspartate receptor, anti-α-amine-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor, anti-gamma-aminobutyric acid receptor 1, and anti-leucine-rich glioma-inactivated 1 encephalitis.
- Key aspects covered include disease occurrence, patient symptoms, and therapeutic strategies.
Impact:
- Enhances understanding of rare autoimmune neurological disorders.
- Provides clinicians with essential information for diagnosing and managing ASE patients.
- Contributes to the neuroimmunology knowledge base regarding synaptic autoimmunity.
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