Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Overview of Primary Immune Regulatory Disorders and Entering the Precision Therapy Era.

The journal of allergy and clinical immunology. In practice·2026
Same author

The Evolving Landscape of JAK-STAT Inhibition in the Treatment of Immune Mediated Inflammatory Diseases.

The Journal of allergy and clinical immunology·2026
Same author

Hospital Environment-Associated Sources of Mycobacterium abscessus Infection in Transplant Recipients.

JAMA network open·2026
Same author

Aberrant STAT signaling and T cell dysregulation define a targetable pediatric sepsis endotype.

The Journal of clinical investigation·2026
Same author

Accuracy of Clinical Phenotype for Diagnosing Adults With Primary Ciliary Dyskinesia.

Chest·2026
Same author

Resolution of PML after Treatment with Virus-Specific T Cells and HCT.

The New England journal of medicine·2026

Related Experiment Video

Updated: May 22, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

Genetic causes of bronchiectasis.

Christine M Gould1, Alexandra F Freeman, Kenneth N Olivier

  • 1Division of Pulmonary & Sleep Medicine, Children's National Medical Center, Northwest, Washington, DC 20010, USA. christine.gould@us.army.mil

Clinics in Chest Medicine
|May 30, 2012
PubMed
Summary

Genetic factors significantly influence bronchiectasis development. Understanding these genetic contributions, including variations and environmental interactions, is crucial for comprehending this complex lung disease.

More Related Videos

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections
06:57

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

Related Experiment Videos

Last Updated: May 22, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections
06:57

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

Area of Science:

  • Pulmonology
  • Genetics
  • Pathophysiology

Background:

  • Bronchiectasis development involves a complex pathologic cycle.
  • Genetic influences play a significant role in its etiology.
  • Previous research utilized genome-wide linkage analysis and candidate gene studies.

Purpose of the Study:

  • To enhance the understanding of the genetic basis of bronchiectasis.
  • To discuss the interplay of various genetic and environmental factors.
  • To explore the complexity of bronchiectasis pathogenesis.

Main Methods:

  • Review of genome-wide linkage analysis findings.
  • Analysis of family-based genetic linkage studies.
  • Evaluation of candidate gene testing results.

Main Results:

  • Genetic factors are integral to bronchiectasis development.
  • Allelic variations and gene modifiers contribute to disease susceptibility.
  • Interactions between host and environmental factors are significant.

Conclusions:

  • A comprehensive understanding of genetic influences is vital for bronchiectasis research.
  • Genetic variations, HLA associations, and environmental factors contribute to disease spectrum.
  • Further research into these interactions will improve understanding of bronchiectasis pathogenesis.