Related Experiment Video
Updated: May 22, 2026
15:43
Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
Published on: March 17, 2014
Bronchiectasis and nontuberculous mycobacterial disease
David E Griffith1, Timothy R Aksamit
1Pulmonary and Critical Care Division, Department of Medicine, University of Texas Health Science Center, Tyler, 75708, USA. david.griffith@uthct.edu
Clinics in Chest Medicine
|May 30, 2012
Summary
Nontuberculous mycobacterial (NTM) lung infections and bronchiectasis are closely linked, with bronchiectasis potentially predisposing individuals to NTM disease. Effective management requires addressing both conditions simultaneously.
Area of Science:
- Pulmonology
- Infectious Diseases
- Microbiology
Background:
- Nontuberculous mycobacterial (NTM) lung infections and bronchiectasis are increasingly recognized as related disorders.
- A growing consensus suggests nodular/bronchiectatic NTM lung disease may arise from pre-existing bronchiectasis.
Purpose of the Study:
- To highlight the close relationship between NTM lung disease and bronchiectasis.
- To emphasize the need for physicians to understand the pathogenic potential of individual NTM species.
- To underscore the importance of managing both NTM infection and bronchiectasis concurrently.
Main Methods:
- Literature review and synthesis of current understanding regarding NTM lung disease and bronchiectasis.
- Analysis of the relationship between NTM species and disease presentation.
- Discussion of diagnostic guidelines and therapeutic strategies.
Main Results:
- NTM lung disease, particularly the nodular/bronchiectatic form, is strongly associated with bronchiectasis.
- Most patients with NTM lung disease also have bronchiectasis.
- Understanding the specific NTM species involved is crucial for effective treatment.
Conclusions:
- Bronchiectasis may predispose individuals to NTM infection and subsequent lung disease.
- Optimal patient care necessitates integrated therapeutic approaches for both NTM infection and bronchiectasis.
- Familiarity with NTM species' pathogenic potential is essential for applying diagnostic guidelines.
Related Concept Videos
01:28Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:29Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:31Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
01:17Other Pulmonary Disorders
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
01:28Pulmonary Tuberculosis V
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...