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CCL2 disrupts the adherens junction: implications for neuroinflammation

Toni K Roberts1, Eliseo A Eugenin, Lillie Lopez

  • 1Department of Pathology, The Albert Einstein College of Medicine, Bronx, NY, USA.

Laboratory Investigation; a Journal of Technical Methods and Pathology
|May 30, 2012
PubMed
Summary

Chemokine CCL2 disrupts brain endothelial adherens junctions via Src-dependent mechanisms. This process involves beta-catenin and PECAM-1, potentially increasing leukocyte entry into the CNS during neuroinflammation.

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