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Related Concept Videos

Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Diversity of Protists I01:15

Diversity of Protists I

Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...

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Updated: May 21, 2026

Transient Transduction of the Strobilated Forms of Echinococcus granulosus
13:25

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Published on: September 16, 2022

Cysticercosis and echinococcosis.

M W Lightowlers1

  • 1Veterinary Clinical Centre, The University of Melbourne, Werribee, Australia, marshall@unimelb.edu.au.

Current Topics in Microbiology and Immunology
|May 30, 2012
PubMed
Summary

New vaccines and treatments offer a One Health approach to control zoonotic parasitic diseases like cysticercosis and cystic echinococcosis by targeting animal hosts, reducing human infections.

Area of Science:

  • Veterinary Medicine
  • Parasitology
  • Public Health

Background:

  • Cysticercosis and cystic echinococcosis are zoonotic parasitic diseases transmitted by livestock.
  • Current control strategies utilize a One Health approach, focusing on animal hosts to reduce human disease.
  • Existing methods require enhanced efficacy and broader application.

Purpose of the Study:

  • To introduce novel vaccines for controlling Echinococcus granulosus and Taenia solium infections in animal hosts.
  • To explore integrated control strategies combining vaccination and taeniacides for comprehensive disease management.
  • To assess the potential of these interventions in reducing the global burden of human parasitic infections.

Main Methods:

  • Development and application of highly effective vaccines against Echinococcus granulosus and Taenia solium.

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Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus

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  • Implementation of taeniacides in definitive hosts to complement vaccination efforts.
  • One Health strategy integrating animal and human health interventions.

    • Main Results:

    • Vaccines demonstrate high efficacy in preventing infections in animal intermediate hosts.
    • Combined vaccination and taeniacide treatments offer a promising new opportunity for disease control.
    • Potential for significant indirect reduction in human cysticercosis and cystic echinococcosis.

    Conclusions:

    • Novel vaccines and taeniacides provide powerful tools for controlling cysticercosis and cystic echinococcosis.
    • The integrated One Health approach, leveraging these new interventions, can substantially decrease the global burden of these zoonotic diseases.