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Developmental status of 1-year-old infants fed breast milk, cow's milk formula, or soy formula
Aline Andres1, Mario A Cleves, Jayne B Bellando
1Arkansas Children’s Nutrition Center, Little Rock, Arkansas 72202, USA. andresaline@uams.edu
Insights
Soy formula supports normal infant development, similar to milk-based formula. Breastfed infants showed slight advantages in cognitive development scores compared to formula-fed infants.
Area of Science:
- Pediatric Nutrition
- Developmental Pediatrics
- Infant Health
Background:
- Concerns exist regarding soy phytochemicals' impact on infant development.
- Soy formula is a common alternative for infants.
Purpose of the Study:
- To compare the developmental status of breastfed (BF), milk-based formula-fed (MF), and soy protein-based formula-fed (SF) infants.
- To assess mental, motor, and language development during the first year of life.
Main Methods:
- Longitudinal assessment of 391 healthy infants at 3, 6, 9, and 12 months.
- Utilized Bayley Scales of Infant Development and Preschool Language Scale-3.
- Employed mixed effects models with adjustments for multiple confounding factors.
Main Results:
- No significant developmental differences were observed between MF and SF infants.
- BF infants demonstrated slightly higher Mental Developmental Index (MDI) scores at 6 and 12 months compared to formula-fed groups.
- BF infants showed higher Psychomotor Development Index scores than SF infants at 6 months and higher language scores than MF infants at 3 and 6 months.
Conclusions:
- All infant groups (BF, MF, SF) exhibited developmental scores within normal ranges.
- Soy formula and milk-based formula support comparable infant development.
- Breastfeeding showed a slight cognitive development advantage over formula feeding.
Background And Objective:
Although soy formula has been reported to support normal development, concerns exist regarding potential adverse developmental effects of phytochemicals associated with soy protein. This study characterized developmental status (mental, motor, and language) of breastfed (BF), milk-based formula-fed (MF), or soy protein-based formula-fed (SF) infants during the first year of life.
Methods:
Healthy infants (N = 391) were assessed longitudinally at ages 3, 6, 9, and 12 months. Development was evaluated by using the Bayley Scales of Infant Development and the Preschool Language Scale-3. Mixed effects models were used while adjusting for socioeconomic status, mother's age and IQ, gestational age, gender, birth weight, head circumference, race, age, and diet history.
Results:
No differences were found between formula-fed infants (MF versus SF). BF infants scored slightly higher than formula-fed infants on the Mental Developmental Index (MDI) score at ages 6 and 12 months (P < .05). Infants who were breastfed also had higher Psychomotor Development Index scores than SF infants at age 6 months and slightly higher Preschool Language Scale-3 scores than MF infants at ages 3 and 6 months (P < .05). In addition, BF infants had a lower probability to score within the lower MDI quartile compared with MF infants and a higher likelihood to score within the upper quartile for the MDI and Psychomotor Development Index compared with SF infants.
Conclusions:
This unique study showed that all scores on developmental testing were within established normal ranges and that MF and SF groups did not differ significantly. Furthermore, this study demonstrated a slight advantage of BF infants on cognitive development compared with formula-fed infants.
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