[An experimental study of the energy metabolism in the cortex of the single denervated kidney]

The long-term study of intratissular contents of ATP, ADP, AMP and the energy charge of the renal cortex in rats under the conditions of experimental combination of compensatory hypertrophy and chronic nervous decentralization enabled the authors to make the conclusion on the chronic energy-deficient status of the tubular cortical zones manifest by a two-wave decrease in the pool and the impaired spectrum of the adenyl system constituents. A negative trophic effect of demediatorization of chronically overloaded tissue of the cortex was found to be responsible for the disorders in the energy metabolism levels in the early phase of the disease and two months later for the progressive hypoperfusion of the cortical tubular system of a single denervated kidney.