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Quantitative Detection of DNA-Protein Crosslinks and Their Post-Translational Modifications
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Quantitative Detection of DNA-Protein Crosslinks and Their Post-Translational Modifications

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[DNA-topoisomerases and their functions in cell]

D A Giliarov, I S Shkundina

    Molekuliarnaia Biologiia
    |May 31, 2012
    PubMed

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    Fixing Double-strand Breaks

    The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
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    The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...