Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

Myasthenia Gravis ll: Pathophysiology

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

Muscles of the Eye

Muscles of the Eye

The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and rotating...

Myasthenia Gravis: Diagnostic Tests

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

Accessory Structures of the Eye

Accessory Structures of the Eye

Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparison between the efficacy and side effects of intravitreal versus anterior chamber Bevacizumab injection in neovascular glaucoma patients.

Journal of medicine and life·2016

Same author

Angioid streaks - a rare cause of neovascular glaucoma. Case report.

Journal of medicine and life·2016

Same author

Topographic measurements of eyelids and orbit in enucleated eyes with hydroxyapatite integrated implant versus PMMA implant.

Journal of medicine and life·2016

Same author

Tear lipocalin, lysozyme and lactoferrin concentrations in postmenopausal women.

Journal of medicine and life·2015

Same author

Hydroxyapatite ocular implant and non-integrated implants in eviscerated patients.

Journal of medicine and life·2015

Same author

Correlations between eyelid tumors and tear lipocalin, lysozyme and lactoferrin concentrations in postmenopausal women.

Journal of medicine and life·2015

Same journal

[Macular serpiginous choroiditis complicated by macular hole].

Oftalmologia (Bucharest, Romania : 1990)·2015

Same journal

[Therapeutic approach in persistent diabetic macular edema].

Oftalmologia (Bucharest, Romania : 1990)·2015

Same journal

[Preliminary results of treatment with aflibercept].

Oftalmologia (Bucharest, Romania : 1990)·2015

Same journal

MANAGEMENT OF DIABETIC RETINOPATHY, PREVALENCE AND CLINICAL CLASSIFICATION.

Oftalmologia (Bucharest, Romania : 1990)·2015

Same journal

[Changes in intraocular pressure depending on posture].

Oftalmologia (Bucharest, Romania : 1990)·2015

Same journal

[Treatment for penetrating wound caused by metallic intraocular foreign body].

Oftalmologia (Bucharest, Romania : 1990)·2015

See all related articles

Search research articles

Related Experiment Video

Updated: May 21, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

[Myasthenia--ocular type].

Andreea-Madalina Stefanescu¹, E Ungureanu, Alina Tugui

¹Reteaua Privata De Sanatate Regina Maria.

Oftalmologia (Bucharest, Romania : 1990)

|May 31, 2012

Summary

This summary is machine-generated.

This case study highlights ocular myasthenia, a condition affecting eye muscles. Early diagnosis by ophthalmologists and neurologists is crucial for effective treatment strategies.

More Related Videos

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Published on: October 13, 2016

Related Experiment Videos

Last Updated: May 21, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Published on: October 13, 2016

Area of Science:

Neurology
Ophthalmology

Background:

Ocular myasthenia gravis is an autoimmune disorder affecting neuromuscular junctions, primarily presenting with ptosis and diplopia.
Early recognition and accurate diagnosis are critical for timely intervention and management of ocular myasthenia.

Observation:

A patient presented with symptoms suggestive of ocular myasthenia, initially suspected by an ophthalmologist.
Neurological confirmation of the diagnosis was obtained, underscoring the collaborative role of different medical specialties.

Findings:

The case underscores the diagnostic challenges and clinical presentation of ocular myasthenia.
Confirmation of the diagnosis involved specialized neurological assessment.

Implications:

This case highlights the importance of interdisciplinary collaboration in diagnosing rare neurological conditions.
Discussion of the latest treatment modalities offers insights into current therapeutic approaches for ocular myasthenia.