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Updated: May 21, 2026

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
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Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

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Nanoparticles biodistribution in the eye.

F Gardikiotis1, Cătălina Peptu, M Popa

  • 1"GR.T. Popa" University of Medicine and Pharmacy Iasi, Faculty of Medicine, Department of Ophthalmology, Romania.

Oftalmologia (Bucharest, Romania : 1990)
|May 31, 2012
PubMed
Summary
This summary is machine-generated.

Chitosan nanoparticles show promise for controlled intraocular drug delivery. These fluorescein-labeled particles demonstrated good biodistribution in pig eyes, reaching the cornea, retina, and optic nerve.

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Area of Science:

  • Ophthalmology
  • Nanotechnology
  • Biomaterials Science

Background:

  • Ocular disease management is hindered by limitations in controlled drug delivery.
  • Developing effective intraocular drug delivery systems is crucial for treating various eye conditions.

Purpose of the Study:

  • To investigate chitosan-based micro and nanoparticles as novel vehicles for intraocular drug delivery.
  • To evaluate the biodistribution of fluorescein-labeled chitosan nanoparticles in pig eyes after administration into the anterior chamber.

Main Methods:

  • Chitosan nanoparticles were prepared using a double crosslinking method in a water/oil emulsion.
  • Particle characterization involved Scanning Electron Microscopy (SEM) and Laser Difractometry.
  • Biodistribution analysis was performed using Confocal Laser Microscopy.

Main Results:

  • The prepared micro and nanoparticles exhibited an average size range of 500 nm to 2 micrometers.
  • Particles displayed a round shape, smooth surface, significant polydispersity, and notable porosity.
  • Good biodistribution was observed across corneal, scleral, retinal, and optic nerve tissues.

Conclusions:

  • Chitosan-based nanoparticles are suitable for intraocular drug delivery.
  • These nanoparticles show potential for future therapeutic applications in conditions like endophthalmitis and age-related macular degeneration.