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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: May 21, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

[Structure-function correlation in early diagnosis of glaucoma progression].

Ana-Maria Dascălu1, Cristina Alexandrescu, Alina Popa-Cherecheanu

  • 1Universitatea de Medicină şi Farmacie "Carol Davila" Bucureşti.

Oftalmologia (Bucharest, Romania : 1990)
|May 31, 2012
PubMed
Summary

Early glaucoma detection relies on structure-function correlations. Structural tests identify progression before functional tests in early stages, while functional tests are better for advanced glaucoma.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Glaucoma is a progressive optic neuropathy characterized by structural damage and functional vision loss.
  • Early detection of glaucoma progression is crucial for timely intervention and preserving vision.

Purpose of the Study:

  • To investigate the correlations between structural and functional changes in the early detection of glaucoma progression.
  • To determine how these correlations vary with the clinical stage of glaucomatous damage.

Main Methods:

  • A prospective study involving 204 patients with primary open-angle glaucoma (POAG) over a 4-year follow-up period.
  • Ophthalmological examinations included cup-to-disc ratio (C/D ratio), Disk Damage Likelihood Scale (DDLS), automated perimetry, and Heidelberg Retina Tomography (HRT).

Main Results:

  • Structural progression was more frequently associated with perimetric progression in moderate to advanced glaucoma.
  • In preperimetric and early glaucoma, structural progression was detected more often (19.04% and 29.3%) than perimetric progression (16.66%).
  • In cases with both structural and functional progression, lesion location correlated better when involving the optic disc poles.

Conclusions:

  • The structure-function relationship in glaucoma progression is dependent on the clinical stage and location of defects.
  • Structural investigations are more sensitive for detecting progression in early glaucoma stages.
  • Functional tests are more effective for early progression detection in advanced glaucoma stages.