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Updated: May 21, 2026

Preparing an Isotopically Pure 229Th Ion Beam for Studies of 229mTh
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Published on: May 3, 2019

Rhenium-188: availability from the (188)W/(188)Re generator and status of current applications.

M R A Pillai1, Ashutosh Dash, F F Knapp

  • 1Radiopharmceuticals Division, Bhabha Atomic Research Centre, Mumbai 400 085, India. mrap@barc.gov.in

Current Radiopharmaceuticals
|May 31, 2012
PubMed
Summary
This summary is machine-generated.

Rhenium-188 (188Re) is a versatile radionuclide for therapy, available via tungsten-188 (188W) generators. Challenges in 188W production and low eluted 188Re concentration limit its broader clinical application despite therapeutic potential.

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Area of Science:

  • Nuclear Medicine
  • Radiopharmaceutical Therapy
  • Medical Isotope Production

Background:

  • Rhenium-188 (188Re) is a readily available generator-derived radionuclide for therapy, emitting therapeutic beta particles and imageable gamma rays.
  • The tungsten-188 (188W)/188Re generator provides a long-term source of no-carrier-added (nca) 188Re for radiopharmaceutical preparation.
  • Despite its utility, challenges in producing high-specific-activity 188W have impeded the widespread application of 188Re.

Purpose of the Study:

  • To review the availability and applications of Rhenium-188 (188Re) in radionuclide therapy.
  • To discuss the limitations and impediments hindering the broader clinical adoption of 188Re.
  • To highlight advancements in overcoming production and concentration challenges for 188Re.

Main Methods:

  • Review of literature on 188W/188Re generator technology and radiopharmaceutical development.
  • Analysis of production routes for the parent radionuclide, 188W.
  • Evaluation of post-elution concentration techniques for 188Re.

Main Results:

  • 188Re offers desirable therapeutic and imaging properties, with the 188W/188Re generator enabling continuous availability.
  • Production of high-specific-activity 188W is limited to a few high-flux reactors, posing a significant challenge.
  • Low radioactive concentration of eluted 188ReO4- necessitates concentration techniques, which have been successfully developed.
  • Early phase clinical studies demonstrate the use of 188Re-based radiopharmaceuticals for various cancers and conditions.

Conclusions:

  • 188Re is a valuable radionuclide for targeted radionuclide therapy, with established generator systems.
  • Production limitations of the parent 188W and initial low eluted concentrations of 188Re are key factors restricting its widespread use.
  • Ongoing development of production methods and concentration techniques is crucial for realizing the full therapeutic potential of 188Re.