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Related Concept Videos

Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
Spermatogenesis01:22

Spermatogenesis

Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
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Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
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RNA Interference

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Updated: May 21, 2026

Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye
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Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye

Published on: January 14, 2021

[Non-coding small RNAs and spermatogenesis].

Yannick Romero1, Pierre Calvel, Serge Nef

  • 1Département de médecine génétique et développement, faculté de médecine, université de Genève, 1, rue Michel-Servet, 1211 Genève 4, Suisse.

Medecine Sciences : M/S
|May 31, 2012
PubMed
Summary
This summary is machine-generated.

Small non-coding RNAs are crucial regulators of spermatogenesis, controlling gene expression for testicular function. This review covers their biogenesis and roles in male reproduction.

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Last Updated: May 21, 2026

Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye
08:21

Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye

Published on: January 14, 2021

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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

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Area of Science:

  • Molecular Biology
  • Genetics
  • Reproductive Biology

Context:

  • Spermatogenesis is a complex biological process regulated at multiple levels.
  • Small non-coding RNAs (ncRNAs) are increasingly recognized as key players in gene regulation.

Purpose:

  • To review recent advances in understanding the role of small ncRNAs in spermatogenesis.
  • To provide a comprehensive overview of small ncRNA biogenesis and function in male reproduction.

Summary:

  • Small non-coding RNAs are vital regulators of gene expression during spermatogenesis.
  • These molecules play critical roles in ensuring proper testicular function and male fertility.
  • Current research highlights their involvement from biogenesis to functional impact.

Impact:

  • This review consolidates fragmented data, offering insights into the mechanisms of male reproductive regulation.
  • It provides a foundation for future research into therapeutic strategies for male infertility.
  • Enhances understanding of the intricate molecular networks governing male reproductive health.