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Expression of insulin-like growth factor II mRNA-binding protein 3 in squamous cell carcinomas of the head and neck

T S Clauditz1, C-J Wang, A Gontarewicz

  • 1Department of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. t.clauditz@uke.de

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|May 31, 2012
PubMed
Abstract

Insights

Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is overexpressed in head and neck squamous cell carcinomas. IMP3 expression is a significant prognostic marker, particularly for oral squamous cell carcinomas (OSCC).

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is implicated in various cancers.
  • IMP3 overexpression suggests a role in carcinogenesis.
  • Limited data exists on IMP3 expression in head and neck squamous cell carcinomas (HNSCC).

Purpose of the Study:

  • To evaluate IMP3 expression in HNSCC.
  • To correlate IMP3 expression with clinicopathologic parameters.
  • To determine IMP3's prognostic value in HNSCC subgroups.

Main Methods:

  • Immunohistochemical analysis of IMP3 on over 400 HNSCC patient samples.
  • Semi-quantitative measurement of IMP3 expression (negative, weak, medium, strong).
  • Correlation with tumor stage, nodal stage, and survival data.

Main Results:

  • Positive IMP3 expression correlated significantly with advanced tumor (pT1-4) and nodal (pN0-3) stages in HNSCC.
  • IMP3 expression showed a significant correlation with overall survival in oral cavity tumors.
  • Multivariate analysis identified IMP3 as an independent predictive marker for oral squamous cell carcinomas (OSCC).

Conclusions:

  • IMP3 expression is a significant finding in HNSCC.
  • IMP3 may serve as an independent prognostic factor for OSCC.
  • Further research into IMP3's role in HNSCC is warranted.

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