Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrophysiological Phenotyping of hiPSC-Derived Atrial Cardiomyocytes Using Automated Patch-Clamp: A Platform for Studying Atrial Inherited Arrhythmias.

Cells·2025
Same author

<i>SCN3A</i>-related neurodevelopmental disorder: Clinical case reports and biophysical characterization.

Channels (Austin, Tex.)·2025
Same author

Voltage-gated sodium channels in excitable cells as drug targets.

Nature reviews. Drug discovery·2025
Same author

Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole.

Nature communications·2024
Same author

Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide-gated (HCN4) channels.

The Journal of general physiology·2024
Same author

Multifocal Ectopic Purkinje Premature Contractions due to neutralization of an <i>SCN5A</i> negative charge: structural insights into the gating pore hypothesis.

bioRxiv : the preprint server for biology·2024
Same journal

Role of NADPH oxidase 2-derived reactive oxygen species in cardiac electrophysiological disorders.

Channels (Austin, Tex.)·2026
Same journal

mTORC2-Na<sub>v</sub>1.2 signaling drives early hyperexcitability in Alzheimer's disease mouse model.

Channels (Austin, Tex.)·2026
Same journal

Role for TREK-1 as a polymodal sensor and regulator of cell activity.

Channels (Austin, Tex.)·2026
Same journal

Quantitative analysis of trafficking defects induced by heterozygous expression of hERG voltage sensor domain variants.

Channels (Austin, Tex.)·2026
Same journal

Transient receptor potential canonical (TRPC) channels in diabetes and associated complications.

Channels (Austin, Tex.)·2026
Same journal

Transient receptor potential channels in <i>Flaviviridae</i> infection: A comprehensive review.

Channels (Austin, Tex.)·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

A hot topic: temperature sensitive sodium channelopathies.

Csilla Egri1, Peter C Ruben

  • 1Department of Biomedical Physiology and Kinesiology; Simon Fraser University; Burnaby, BC, Canada.

Channels (Austin, Tex.)
|May 31, 2012
PubMed
Summary
This summary is machine-generated.

Genetic mutations in voltage-gated sodium channels (NaV) can cause temperature-sensitive disorders. Understanding these channelopathies is crucial for developing effective treatments for temperature-related diseases.

More Related Videos

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

Recapitulation of an Ion Channel IV Curve Using Frequency Components
10:14

Recapitulation of an Ion Channel IV Curve Using Frequency Components

Published on: February 8, 2011

Related Experiment Videos

Last Updated: May 21, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

Recapitulation of an Ion Channel IV Curve Using Frequency Components
10:14

Recapitulation of an Ion Channel IV Curve Using Frequency Components

Published on: February 8, 2011

Area of Science:

  • Physiology
  • Genetics
  • Molecular Biology

Background:

  • Body temperature significantly impacts cellular functions.
  • Homeostatic balance is delicate and can be disrupted by genetic mutations.
  • Channelopathies, specifically affecting ion channels, can lower the threshold for temperature-induced physiological disturbances.

Purpose of the Study:

  • To review the functional consequences of identified voltage-gated sodium (NaV) channelopathies.
  • To focus on channelopathies presenting with a temperature-sensitive phenotype.
  • To highlight the importance of genotype-environment interactions in disease etiology and treatment.

Main Methods:

  • Literature review of identified voltage-gated sodium (NaV) channelopathies.
  • Analysis of functional consequences associated with these channelopathies.
  • Synthesis of information regarding temperature-sensitive phenotypes and genetic factors.

Main Results:

  • Identified voltage-gated sodium (NaV) channelopathies can lead to disorders with temperature-sensitive symptoms.
  • Specific genetic mutations alter the normal physiological response to temperature changes.
  • The relationship between specific genotypes and environmental (temperature) triggers is a key factor in disease manifestation.

Conclusions:

  • Voltage-gated sodium (NaV) channelopathies are linked to temperature-sensitive disorders.
  • Understanding the interplay between genetic mutations and environmental factors is essential for disease comprehension.
  • This knowledge is vital for the development of targeted and safe therapeutic strategies for affected individuals.