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Pasteurella multocida: diseases and pathogenesis

I W Wilkie1, M Harper, J D Boyce

  • 1Department of Microbiology, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, VIC 3800, Australia.

Current Topics in Microbiology and Immunology
|May 31, 2012
PubMed

Insights

Pasteurella multocida causes diverse diseases across many hosts, but its pathogenic mechanisms and host specificity are poorly understood. Genetic tools and genome data offer new avenues to explore these enigmatic aspects of this pathogen.

Area of Science:

  • Veterinary Microbiology
  • Infectious Diseases
  • Bacteriology

Background:

  • Pasteurella multocida is a significant pathogen affecting a wide range of animal species.
  • It is associated with numerous distinct clinical syndromes, yet the underlying mechanisms remain largely unknown.
  • Similarities in biochemical and serological properties among strains causing different diseases obscure host specificity.

Purpose of the Study:

  • To investigate the poorly understood pathogenic mechanisms of Pasteurella multocida.
  • To elucidate the molecular basis for host predilection in Pasteurella multocida infections.
  • To leverage recent advancements in genetic manipulation and genomics to understand disease associations.

Main Methods:

  • Utilizing genetic manipulation systems for targeted studies of Pasteurella multocida.
  • Analyzing multiple available genome sequences of Pasteurella multocida strains.
  • Comparing biochemical and serological properties of different Pasteurella multocida isolates.

Main Results:

  • Pathogenic mechanisms for most Pasteurella multocida-associated syndromes are not well-defined.
  • The molecular basis for why Pasteurella multocida infects specific hosts is currently unknown.
  • Similarities in organism properties complicate the understanding of disease causation.

Conclusions:

  • Recent advances in genetic tools and genome sequencing hold promise for unraveling Pasteurella multocida's pathogenicity.
  • These technologies are expected to clarify the links between specific hosts, pathological conditions, and Pasteurella multocida.
  • Further research using these tools is crucial for understanding this enigmatic pathogen.

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