Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Retina

The Retina

The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Short communication: Screening stable flies and house flies as potential vectors of digital dermatitis in dairy cattle.

Journal of dairy science·2020

Same author

Automated estrous detection using multiple commercial precision dairy monitoring technologies in synchronized dairy cows.

Journal of dairy science·2019

Same author

Graffinity: Visualizing Connectivity in Large Graphs.

Computer graphics forum : journal of the European Association for Computer Graphics·2018

Same author

Corticostriatal circuit defects in Hoxb8 mutant mice.

Molecular psychiatry·2017

Same author

Corticostriatal circuit defects in Hoxb8 mutant mice.

Molecular psychiatry·2017

Same author

Influence of breed, milk yield, and temperature-humidity index on dairy cow lying time, neck activity, reticulorumen temperature, and rumination behavior.

Journal of dairy science·2017

Same journal

Correction: Clinical practice guideline for anterior segment dysgenesis.

Japanese journal of ophthalmology·2026

Same journal

Association between subjective symptoms and severity in patients with Fuchs endothelial corneal dystrophy.

Japanese journal of ophthalmology·2026

Same journal

Prevalence and clinical characteristics of Terson syndrome among survivors of aneurysmal subarachnoid hemorrhage: a nationwide study in Japan.

Japanese journal of ophthalmology·2026

Same journal

Epidemiology and treatment trends of retinopathy of prematurity: a multi-center study involving four Asian centers and one European center (2016-2023).

Japanese journal of ophthalmology·2026

Same journal

Clinical characteristics of angioid streaks in Japanese patients.

Japanese journal of ophthalmology·2026

Same journal

Preoperative risk factors for uncontrolled intraocular pressure after vitrectomy combined with intrascleral fixation of the intraocular lens.

Japanese journal of ophthalmology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 21, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

Retinal remodeling.

B W Jones¹, M Kondo, H Terasaki

¹Department of Ophthalmology, Moran Eye Center, University of Utah, 65 Mario Capecchi Dr., Salt Lake City, UT 84132, USA. bryan.jones@m.cc.utah.edu

Japanese Journal of Ophthalmology

|May 31, 2012

Summary

This summary is machine-generated.

Retinal degenerative diseases cause structural and functional changes called retinal remodeling. Understanding this remodeling is key to developing new therapies for vision loss.

More Related Videos

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

LipidUNet-Machine Learning-Based Method of Characterization and Quantification of Lipid Deposits Using iPSC-Derived Retinal Pigment Epithelium

LipidUNet-Machine Learning-Based Method of Characterization and Quantification of Lipid Deposits Using iPSC-Derived Retinal Pigment Epithelium

Published on: July 28, 2023

Related Experiment Videos

Last Updated: May 21, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

LipidUNet-Machine Learning-Based Method of Characterization and Quantification of Lipid Deposits Using iPSC-Derived Retinal Pigment Epithelium

LipidUNet-Machine Learning-Based Method of Characterization and Quantification of Lipid Deposits Using iPSC-Derived Retinal Pigment Epithelium

Published on: July 28, 2023

Area of Science:

Ophthalmology
Neuroscience
Genetics

Background:

Retinal photoreceptor degeneration, caused by genetic mutations or other insults, leads to various vision impairments like retinitis pigmentosa and age-related macular degeneration.
All retinal insults, including trauma, result in retinal remodeling, a process where the neural retina adapts to photoreceptor input loss through negative plasticity.
This remodeling involves molecular, synaptic, cellular, and tissue-level changes across all retinal cell types, including neurons and glia.

Purpose of the Study:

To explore the phenomenon of retinal remodeling following photoreceptor degeneration.
To highlight the implications of retinal remodeling for vision restoration strategies.
To identify potential therapeutic interventions targeting retinal remodeling.

Main Methods:

Review of existing literature on retinal photoreceptor degeneration and associated molecular/cellular changes.
Analysis of the impact of retinal remodeling on neural retina structure and function.
Identification of therapeutic targets within the remodeling process.

Main Results:

Retinal remodeling is a universal response to photoreceptor degeneration, characterized by negative plasticity and phased structural/functional revisions.
Remodeling corrupts the neural retina's ability to integrate surrogate photoreceptor input, complicating bionic and biological vision restoration.
The study of remodeling reveals opportunities for interventions to slow photoreceptor loss, arrest remodeling, or utilize optogenetics.

Conclusions:

Retinal remodeling is a critical factor influencing the success of vision restoration therapies.
Therapeutic strategies should consider modulating or targeting retinal remodeling processes.
Further research into retinal remodeling may unlock novel approaches for treating vision loss.