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Updated: May 21, 2026

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Pipeline for Planning and Execution of Transcranial Ultrasound Neuromodulation Experiments in Humans
Published on: June 28, 2024
[Innovations in neuro-monitoring using transcranial ultrasound]
A Harloff1, W D Niesen, M Reinhard
1Neurologische, Universitätsklinik Freiburg. andreas.harloff@uniklinikfreiburg.de
Fortschritte Der Neurologie-Psychiatrie
|May 31, 2012
Summary
Transcranial ultrasound offers non-invasive neuromonitoring for brain structures and blood flow. This bedside technique avoids risks associated with transporting critically ill patients for CT or MRI scans.
Area of Science:
- Neurology
- Medical Imaging
- Neurosurgery
Background:
- Transcranial ultrasound provides non-invasive, bedside imaging for neuromonitoring.
- Current methods like CT/MRI pose risks due to patient transportation.
- There is a need for safer, more accessible neuromonitoring techniques.
Purpose of the Study:
- To review transcranial ultrasound-based neuromonitoring techniques.
- To highlight the advantages of non-invasive, bedside brain imaging.
- To present the current state of experimental ultrasound applications in neurocritical care.
Main Methods:
- Assessment of changes in brain structures and cerebral blood flow over time.
- Utilizing techniques such as pulsatility index, cerebral venous blood flow, and midline shift measurements.
- Employing transcranial duplex sonography for hemorrhage detection and surgical guidance.
Main Results:
- Transcranial ultrasound enables non-invasive assessment of increased cerebral pressure.
- It can detect intracranial hemorrhage and assist in neurosurgical interventions.
- The review covers cerebral autoregulation monitoring and sonothrombolysis for arterial thrombosis.
Conclusions:
- Transcranial ultrasound is a valuable tool for non-invasive neuromonitoring at the bedside.
- It offers a safe alternative to CT/MRI, reducing transport risks and costs.
- Further development of experimental ultrasound techniques holds promise for neurocritical care.

