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Association between high-sensitivity C-reactive protein and N-Terminal Pro-B-Type Natriuretic Peptide in patients

Wenliang Che1, Buchun Zhang, Wenling Liu

  • 1Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China. chewenliang@tongji.edu.cn

Mediators of Inflammation
|May 31, 2012
PubMed

Insights

Hepatitis C virus (HCV) patients showed lower high-sensitivity C-reactive protein (hs-CRP) levels but a significant correlation between hs-CRP and N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP). This suggests a link between inflammation and cardiac function in HCV infection.

Area of Science:

  • Cardiology
  • Hepatology
  • Inflammation Research

Background:

  • Previous research indicates elevated N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and potential left ventricular diastolic dysfunction in Hepatitis C Virus (HCV) infected patients.
  • Investigating high-sensitivity C-reactive protein (hs-CRP) characteristics and its clinical correlations in HCV patients is crucial.

Purpose of the Study:

  • To examine the characteristics of hs-CRP in HCV-infected patients.
  • To determine the correlation between hs-CRP and clinical profiles, including NT-proBNP and echocardiographic variables.

Main Methods:

  • A study involving 106 HCV-infected patients and 106 healthy controls.
  • Serum hs-CRP and NT-proBNP levels were measured.
  • Regression analysis was used to identify independent correlates of hs-CRP.

Main Results:

  • Serum hs-CRP levels were significantly lower in HCV patients compared to controls (P = 0.012).
  • A significant linear correlation was found between hs-CRP and NT-proBNP in HCV patients (r = 0.392, P = 0.017).
  • Independent correlates of hs-CRP included older age and higher NT-proBNP levels.

Conclusions:

  • Despite significantly decreased hs-CRP levels in HCV patients, a significant association exists between hs-CRP and NT-proBNP.
  • These findings highlight a potential link between inflammatory markers and cardiac biomarkers in HCV infection.
Abstract

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