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Published on: January 26, 2016
[Progress in the study of some important natural bioactive cyclopeptides]
Wen-Yan Xu1, Si-Meng Zhao, Guang-Zhi Zeng
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|May 31, 2012
Summary
Natural cyclopeptides, found across diverse life forms, exhibit potent bioactivities. This review details their discovery, chemical properties, and therapeutic potential, highlighting compounds used in clinics and drug development.
Area of Science:
- Natural product chemistry
- Medicinal chemistry
- Pharmacology
Background:
- Cyclopeptides are prevalent in nature, originating from bacteria, plants, and animals.
- These molecules possess complex structures, often featuring non-canonical amino acids and linkages.
- Natural cyclopeptides display a wide array of significant biological activities.
Purpose of the Study:
- To review recent advancements in the chemical and bioactive studies of natural cyclopeptides.
- To highlight key cyclopeptides with therapeutic applications, including antibiotics, immunosuppressants, and anti-tumor agents.
- To summarize progress in discovery, bioactivity, mechanism of action, quantitative structure-activity relationships (QSAR), and synthesis.
Main Methods:
- Literature review of natural cyclopeptides and their associated research.
- Analysis of chemical structures and biological activities of selected compounds.
- Examination of studies on drug discovery, mechanism of action, QSAR, and synthesis.
Main Results:
- Identified eight key natural cyclopeptides (1-8) with diverse bioactivities.
- Compounds 1-4 are clinically approved drugs (antibiotics, immunosuppressants).
- Compounds 5-8 are in clinical trials or under investigation for anti-tumor and other therapeutic uses.
Conclusions:
- Natural cyclopeptides represent a rich source of therapeutic agents.
- Continued research into their chemistry and bioactivity is crucial for drug discovery.
- These compounds hold significant promise for treating various diseases.
