Group C streptococcal sinusitis

P G Gallagher1, C M Myer, K Crone

  • 1Children's Hospital Medical Center, Cincinnati, OH 45229-2899.

Insights

Group C streptococci are increasingly causing infections. In children, group C streptococcal sinusitis can lead to severe complications, including death, highlighting the need for prompt diagnosis and treatment.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pediatrics

Background:

  • Group C streptococci are recognized as significant human pathogens.
  • Sinusitis can be a serious infection, particularly in pediatric patients.

Observation:

  • A case of group C streptococcal sinusitis in a 6-year-old girl is presented.
  • Four additional cases of group C streptococcal sinusitis in patients under 18 years old were reviewed.
  • Common features included young age, central nervous system complications, and delayed treatment.

Findings:

  • Three of the five pediatric patients had bacteremia (bacteria in the bloodstream) due to group C streptococci.
  • Two patients with group C streptococcal sinusitis and bacteremia unfortunately died.
  • The study underscores the potential severity of group C streptococcal infections.

Implications:

  • Serogrouping is crucial when beta-hemolytic streptococci are isolated from sinus cultures.
  • Prompt initiation of appropriate antimicrobial therapy is essential upon identifying group C streptococci.
  • Clinicians should maintain a high index of suspicion for suppurative intracranial complications in these cases.

Related Concept Videos

Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...
Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...