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Published on: May 5, 2018
[Parental smoking during early pregnancy and congenital heart defects]
Ghassan Chehab1, Issam El-Rassi, Atika Adhami
1Pediatric Department, CHU Hôtel-Dieu de France, Beirut ,Lebanon. ChehabGh@cyberia.net.lb
Insights
Parental smoking during early pregnancy is linked to congenital heart defects like valvar pulmonary stenosis and coarctation of the aorta. Quitting smoking before pregnancy may reduce these risks.
Area of Science:
- Cardiology
- Public Health
- Reproductive Health
Context:
- Congenital heart defects (CHD) are a significant global health concern.
- Parental lifestyle factors, including smoking, are investigated for their impact on fetal development.
- Understanding environmental influences during early pregnancy is crucial for prevention strategies.
Purpose:
- To investigate the association between parental smoking during early pregnancy and the incidence of various congenital heart defects (CHD).
- To identify specific types of CHD that may be linked to parental smoking.
- To provide evidence for public health recommendations regarding smoking cessation.
Summary:
- A 4.5-year study analyzed echocardiography data from 3259 children, comparing those with and without CHD.
- Maternal smoking of ≥20 cigarettes/day was associated with valvar pulmonary stenosis (VPS).
- Both parents smoking ≥20 cigarettes/day correlated with VPS and coarctation of the aorta.
Impact:
- Parental smoking, particularly heavy smoking, is identified as a modifiable risk factor for specific CHDs.
- Findings suggest that parental smoking cessation before conception could lower the occurrence of VPS and coarctation of the aorta.
- Highlights the importance of preconception counseling on smoking cessation for expectant parents.
Objectives:
Analyze the possible role that can play parental smoking during early pregnancy on the occurrence of different types of congenital heart defects (CHD).
Materials And Methods:
Over a period of 4.5 years (between January 1, 2006 and June 30, 2010), data on all children who had an echocardiography were collected and entered in the National Register of Paediatric and Congenital Heart Disease, Lebanese Society of Cardiology, Beirut. Patients were divided into two groups: group I without CHD, and group II with CHD. Variables recorded were: age of mother, place of residence, parental smoking, the type of CHD, the sex of the child and consanguinity of the parents. We used nonparametric tests for comparing the two populations. The p value was considered significant when inferior to 0.05.
Results:
Group I consisted of 2466 patients and group II of 793 patients. Only valvar pulmonary stenosis (VPS) was highly associated with mothers who smoked 20 cigarettes or more per day (p = 0.03). When the mother and father consumed at least 20 cigarettes per day, VPS and coarctation of the aorta were associated with a significant p-value (0.03 and 0.02 respectively).
Conclusion:
Parental smoking in early pregnancy can be considered a risk factor for valvar pulmonary stenosis and coarctation of the aorta. Cessation of smoking by the parents before pregnancy could reduce the risk of their occurrence.
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