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Discovery, development and effectiveness of coagulation-inhibiting drugs for stroke therapy

Monika Killer1, Eugen Trinka, Jörg Kraus

  • 1Head of Neurointervention, University Clinic Salzburg, Christian Doppler Clinic, Department of Neurology, Ignaz Harrer Str. 79, 5020 Salzburg, Austria +43 662 4483 56058 ; +43 662 3924 ; m.killer@salk.at.

Expert Opinion on Drug Discovery
|June 1, 2012
PubMed
Abstract

Insights

This review covers modern antithrombotic drugs for stroke prevention and treatment. Future therapies must balance clotting prevention with reduced hemorrhage risk for better stroke management.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Stroke is a leading cause of death and disability in the US.
  • Current stroke therapy relies on various drugs and strategies, with limited evidence for many.
  • Ongoing clinical trials aim to expand scientific data on stroke management.

Purpose of the Study:

  • To provide an overview of current antithrombotic drugs for stroke prevention and treatment.
  • To discuss future therapeutic prospects in stroke management.

Main Methods:

  • Literature review of modern coagulation-inhibiting drugs.
  • Analysis of ongoing and completed clinical trials for stroke therapy.

Main Results:

  • Limited number of antithrombotic drugs have proven efficacy for stroke.
  • Extensive research is underway to identify more effective treatments.

Conclusions:

  • Cost-effective therapies and enhanced prevention programs are crucial to reduce stroke's impact.
  • Novel drugs are needed to inhibit blood clotting and prevent stroke without increasing bleeding risk.

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