Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intra-slide calibration technology improves immunohistochemical harmonization within and between anatomic pathology laboratories.

bioRxiv : the preprint server for biology·2026
Same author

Weak supervision of H&E slides reveals systems-level biology and functional states that govern therapeutic resistance.

bioRxiv : the preprint server for biology·2026
Same author

Mobile device smartphones for intraoperative diagnosis at the University Hospital Trust of Modena/UNIMORE: from validation process to costs analysis.

Diagnostic pathology·2026
Same author

Bridging the Gap: Digital Adaptation in Low-Resource Settings.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP·2026
Same author

Interrater Variability in the Application of the Goldman Criteria to Medical Autopsies.

Archives of pathology & laboratory medicine·2026
Same author

The critical role of standards for AI in digital pathology: Digital Pathology Association Concept Paper.

Journal of pathology informatics·2026
Same journal

Assessing Human Epidermal Growth Factor Receptor 2 in Urothelial Carcinoma: Insights From Clinical Practice Into Scoring Criteria, Histologic Subtypes, and Genomic Characteristics Across Disease Sites.

Archives of pathology & laboratory medicine·2026
Same journal

Cross-Reactivity of TPIT Antibody Clone OTI2G1 in Chordoma: Structural Mechanisms and Diagnostic Implications.

Archives of pathology & laboratory medicine·2026
Same journal

Paracoccidioidomycosis at Autopsy: A Case Series and Literature Review.

Archives of pathology & laboratory medicine·2026
Same journal

Accuracy of Cytology Diagnosis for Well Differentiated Neuroendocrine Tumors: Assessment by the College of American Pathologists Non-Gynecologic Slide Program.

Archives of pathology & laboratory medicine·2026
Same journal

Serum Immunofixation Electrophoresis Guidance Conflict: A Call to Harmonize.

Archives of pathology & laboratory medicine·2026
Same journal

In Reply.

Archives of pathology & laboratory medicine·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Renal primitive neuroectodermal tumors.

Tanner Bartholow1, Anil Parwani

  • 1Department of Pathology, University of Pittsburgh School of Medicine,UPMC Shadyside Hospital, 5230 Centre Ave, Pittsburgh, PA15232, USA.

Archives of Pathology & Laboratory Medicine
|June 1, 2012
PubMed
Summary
This summary is machine-generated.

Primitive neuroectodermal tumors (PNETs) are rare in the kidney but are aggressive. Accurate diagnosis relies on histology, immunohistochemistry (CD99), and genetics to differentiate from other renal tumors.

More Related Videos

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
03:53

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

Related Experiment Videos

Last Updated: May 21, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
03:53

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

Area of Science:

  • Oncology
  • Pathology

Background:

  • Primitive neuroectodermal tumors (PNETs) are part of the Ewing sarcoma family.
  • While typically found in the chest wall and paraspinal regions, renal PNETs are increasingly reported.
  • These aggressive tumors affect young adults, with a 5-year disease-free survival rate of 45-55%.

Purpose of the Study:

  • To review the diagnostic features of renal primitive neuroectodermal tumors.
  • To highlight key histological, immunohistochemical, and genetic markers for accurate diagnosis.
  • To differentiate renal PNETs from other renal malignancies.

Main Methods:

  • Review of histological features, including characteristic pseudorosettes.
  • Analysis of immunohistochemical markers, with a focus on CD99.
  • Examination of genetic abnormalities associated with PNETs.

Main Results:

  • Renal PNETs exhibit specific histological patterns and immunohistochemical profiles.
  • CD99 is a crucial marker for diagnosing PNETs.
  • Genetic analysis aids in distinguishing PNETs from other renal tumors.

Conclusions:

  • Accurate diagnosis of renal PNETs requires a comprehensive approach.
  • Understanding histological, immunohistochemical, and genetic features is essential for correct identification.
  • Distinguishing renal PNETs is critical due to their aggressive nature and treatment implications.