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Published on: April 28, 2022
Changes in the intestinal microbiota from adulthood through to old age
1Department of Microbiology and Alimentary Pharmabiotic Centre, University College, Cork, Ireland. pwotoole@ucc.ie
Summary
The gut microbiota of older adults varies significantly and differs from younger adults. Modulating the intestinal microbiota may enhance nutrition and health in the elderly.
Area of Science:
- Microbiology
- Gerontology
- Human Health
Background:
- The human intestinal microbiota is a complex community, with composition detailed by culture-independent methods.
- While adult gut microbiota is stable, it fluctuates in infants and the elderly.
- Changes in gut microbiota are linked to various health issues.
Purpose of the Study:
- To examine the composition and function of the intestinal microbiota in 500 Irish adults over 65.
- To identify differences compared to younger adults and assess health parameters.
Main Methods:
- Faecal microbiota analysis using amplicon pyrosequencing.
- Measurement of medical, biochemical, and immunological parameters in subjects.
Main Results:
- Significant inter-individual variation in gut microbiota composition was observed.
- Distinct differences in microbiota were found in older adults compared to younger adults.
- Specific bacterial phyla proportions varied significantly among individuals.
Conclusions:
- The gut microbiota composition differs between older and younger adults.
- Modulating the intestinal microbiota in older individuals could improve nutrition and health.
- Further research into microbiota modulation for elderly health is warranted.
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