Qualitative and quantitative approaches in comprehensive two-dimensional gas chromatography

Area of Science:

• Analytical Chemistry
• Chromatography

Background:

• One-dimensional gas chromatography (GC) has limitations in resolving complex mixtures.
• Comprehensive two-dimensional gas chromatography (GC×GC) offers superior separation power.

Purpose of the Study:

• To review qualitative and quantitative analytical approaches using GC×GC.
• To highlight GC×GC advantages such as high peak capacity and signal enhancement.

Main Methods:

• Exploration of targeted analysis strategies.
• Discussion of non-targeted, group, and fingerprinting analysis techniques.
• Review of how GC×GC overcomes challenges in complex sample analysis.

Main Results:

• GC×GC provides structured chromatograms for improved data interpretation.
• Enhanced peak capacity allows for the resolution of previously inseparable compounds.
• Signal enhancement improves detection limits for trace analytes.

Conclusions:

• GC×GC is a powerful tool for solving complex analytical problems.
• The reviewed approaches demonstrate the versatility of GC×GC in various analytical contexts.