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Updated: May 21, 2026

Merkel Cell Polyomavirus Infection and Detection
Published on: February 7, 2019
[Merkel cell carcinoma during treatment with TNF-alpha inhibitors: coincidence or warning?]
Suzanne P Linn-Rasker1, G A van Albada-Kuipers, Stefan V Dubois
1Meander Medisch Centrum, Amersfoort. s.linn@meandermc.nl
Background:
Increasing numbers of patients are being treated with TNF-alpha inhibitors. Two patients in our outpatient clinic developed Merkel cell carcinoma during treatment with TNF alpha inhibitors. Since this is a very rare malignancy, this is a remarkable observation.
Case Description:
A 70-year-old male with rheumatoid arthritis had been treated with etanercept for two years when he discovered a nodule on his elbow that started growing rapidly. It was diagnosed as Merkel cell carcinoma. Despite treatment, the patient died 2 years later.
Conclusion:
Merkel cell carcinoma is an aggressive malignancy with a clinically benign aspect. Patients treated with TNF-alpha inhibitors possibly have an increased risk of developing this malignancy.
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