Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Binge Eating Disorders01:23

Binge Eating Disorders

Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
Anorexia Nervosa01:28

Anorexia Nervosa

Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lifestyle Intervention During Pregnancy Is Associated With Favourable Changes of Vitronectin in Women With Obesity: Results From the Randomised LiP Trial.

Clinical obesity·2026
Same author

Her Eating Advice: Eat Dessert First: Remembering Judith S. Stern, ScD, RD.

The Journal of nutrition·2026
Same author

Impact of maternal fasting blood glucose in pregnancy on body composition, anthropometric, and metabolic outcomes in newborns and 3-Year-Old offspring: results from the lifestyle in pregnancy and offspring study.

BMC pregnancy and childbirth·2026
Same author

Study protocol for a 15-year follow-up of a randomized controlled trial on lifestyle intervention in pregnancy: assessing long-term effects on body composition, metabolic traits, and mental health in mothers and offspring.

Trials·2026
Same author

Preexisting Diabetes and Pregnancy: An Endocrine Society and European Society of Endocrinology Joint Clinical Practice Guideline.

European journal of endocrinology·2025
Same author

Preexisting Diabetes and Pregnancy: An Endocrine Society and European Society of Endocrinology Joint Clinical Practice Guideline.

The Journal of clinical endocrinology and metabolism·2025

Related Experiment Video

Updated: May 21, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Severe obesity: the neglected epidemic.

John G Kral1, Ruth A Kava, Patrick M Catalano

  • 1Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY, USA.

Obesity Facts
|June 1, 2012
PubMed
Summary

Severe obesity (SO) is rapidly increasing, leading to significant health issues and high healthcare costs. Bariatric surgery offers a cost-effective, preventive, and therapeutic solution for SO, though access and long-term care require improvement.

More Related Videos

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

Related Experiment Videos

Last Updated: May 21, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

Area of Science:

  • Medical Science
  • Public Health
  • Surgical Innovation

Background:

  • Severe obesity (SO) is a growing epidemic in adults and children, surpassing general obesity rates.
  • SO is linked to numerous comorbidities, substantial healthcare expenditures, and adverse pregnancy outcomes.
  • It also poses a high risk for offspring obesity into adulthood.

Purpose of the Study:

  • To highlight the increasing prevalence and impact of severe obesity.
  • To advocate for bariatric surgery as the primary treatment for severe obesity.
  • To address the need for improved access to surgical care and long-term postoperative management.

Main Methods:

  • Review of current literature on severe obesity and bariatric surgery outcomes.
  • Analysis of healthcare costs associated with severe obesity and its treatments.
  • Evaluation of the preventive and therapeutic benefits of bariatric surgery.
  • Discussion of the importance of multidisciplinary, long-term postoperative care and patient education.

Main Results:

  • Bariatric surgery is the most effective treatment for durable weight loss in severe obesity.
  • Despite increased global procedures, access to bariatric surgery remains limited for eligible patients.
  • Surgical treatment is cost-effective compared to conventional nonoperative management.
  • Long-term, multidisciplinary follow-up is crucial for managing surgical risks and optimizing outcomes.

Conclusions:

  • Severe obesity requires urgent public health attention due to its escalating prevalence and associated health burdens.
  • Bariatric surgery is a vital, cost-effective intervention for severe obesity, necessitating improved patient access.
  • Comprehensive, lifelong postoperative care and patient education are essential for successful bariatric surgery outcomes.