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Related Concept Videos

Autophagy01:27

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Phagocytosis00:41

Phagocytosis

Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.

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Emerging mechanistic insights of selective autophagy in hepatic diseases.

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Autophagy is the key to making chronic wounds acute in skin wound healing.

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A novel role of ATG9A and RB1CC1/FIP200 in mediating cell-death checkpoints to repress TNF cytotoxicity.

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Related Experiment Video

Updated: May 21, 2026

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body
06:02

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body

Published on: August 4, 2022

The autophagy community.

Daniel J Klionsky

    Autophagy
    |June 1, 2012
    PubMed
    Summary
    This summary is machine-generated.

    The global autophagy research community, defined by shared interests and distinct identity, benefits from enhanced connection. This work proposes a mechanism to strengthen this scientific community.

    Keywords:
    lysosomemethodspeoplestressvacuole

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    Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

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    Activating Autophagy by Aerobic Exercise in Mice
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    Activating Autophagy by Aerobic Exercise in Mice

    Published on: February 3, 2017

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    Last Updated: May 21, 2026

    Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body
    06:02

    Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body

    Published on: August 4, 2022

    Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
    11:39

    Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

    Published on: July 21, 2017

    Activating Autophagy by Aerobic Exercise in Mice
    08:44

    Activating Autophagy by Aerobic Exercise in Mice

    Published on: February 3, 2017

    Area of Science:

    • Cellular Biology
    • Molecular Biology

    Background:

    • Defining 'community' through shared characteristics and distinct identity.
    • Identifying the global autophagy research group as a distinct scientific community.

    Discussion:

    • Exploring the sense of belonging and the necessity of a community for autophagy researchers.
    • Proposing a mechanism to foster a stronger sense of community within autophagy research.

    Key Insights:

    • The autophagy research field constitutes a distinct global community.
    • A strong community enhances scientific progress and collaboration.
    • A proposed mechanism aims to bolster the autophagy community.

    Outlook:

    • Further development of community-building initiatives in autophagy research.
    • Strengthening global collaboration and knowledge sharing in autophagy.
    • Enhancing the collective identity and impact of the autophagy research community.