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Updated: May 21, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Computational genetic discoveries that could improve perioperative medicine
Ming Zheng1, David Dill, J David Clark
1Department of Anesthesia, Stanford University, School of Medicine, Stanford, California, USA.
Purpose Of Review:
The review examines the rationale and translational utility of computational genetic studies using murine models of biomedical traits.
Recent Findings:
Computational genetic mapping studies have identified the genetic basis for biomedical trait differences in 16 different murine models, including several that are of importance to perioperative medicine.
Summary:
The results have generated new treatments for alleviating incisional pain and narcotic drug withdrawal symptoms, which are now in clinical trials. A recent study identified allelic differences affecting chronic pain responses in mice and humans, which may enable a new 'personalized' approach to treating chronic pain.
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