Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of redox-regulated components of arsenate (As(V)) tolerance through thiourea supplementation in rice.

Metallomics : integrated biometal science·2014
Same author

Nutraceutical potential of Aerva lanata (L.) Juss. ex Schult ameliorates secondary complications in streptozotocin-induced diabetic rats.

Food & function·2014
Same author

An early South Asian dust storm during March 2012 and its impacts on Indian Himalayan foothills: a case study.

The Science of the total environment·2014
Same author

Immunogenicity of DNA-advanced glycation end product fashioned through glyoxal and arginine in the presence of Fe³⁺: its potential role in prompt recognition of diabetes mellitus auto-antibodies.

Chemico-biological interactions·2014
Same author

Cu-Ni nanoparticle-decorated graphene based photodetector.

Nanoscale·2014
Same author

Enhanced performance configuration for fast-switching deformed helix ferroelectric liquid crystal continuous tunable Lyot filter.

Applied optics·2014
Same journal

Propylene carbonate-PVDF-HFP/MXene-based self-powered biosensor for auxiliary detection of salivary exosomal miRNA-155 in pediatric asthma.

Biosensors & bioelectronics·2026
Same journal

Nanostructured zinc-coordination supraparticles on cellulose fibers: A 3D-Printed μ-FAD integrated smartphone platform for multiplexed salivary metabolic monitoring.

Biosensors & bioelectronics·2026
Same journal

Reliable biomarker monitoring at microneedle aptamer biosensors using a dual-frequency ratiometric approach: Overcoming signal drifts.

Biosensors & bioelectronics·2026
Same journal

Interfacial structure-modified nanozyme drives single-receptor-single-reaction-unit multichannel sensor array for pesticide discrimination.

Biosensors & bioelectronics·2026
Same journal

A real-time 5-hydroxytryptamine monitoring system applicable both in vitro and in vivo.

Biosensors & bioelectronics·2026
Same journal

Recent developments of textile-based triboelectric nanogenerators for smart sports applications.

Biosensors & bioelectronics·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

Fluorescent Lateral Flow Immunoassay Based on Quantum Dots Nanobeads
07:13

Fluorescent Lateral Flow Immunoassay Based on Quantum Dots Nanobeads

Published on: June 28, 2024

Chitosan encapsulated quantum dots platform for leukemia detection.

Aditya Sharma1, Chandra Mouli Pandey, Gajjala Sumana

  • 1Department of Science & Technology Centre on Biomolecular Electronics, Biomedical Instrumentation Section, Materials Physics & Engineering Division, National Physical Laboratory (Council of Scientific & Industrial Research), Dr K.S. Krishnan Marg, New Delhi 110012, India.

Biosensors & Bioelectronics
|June 1, 2012
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel chitosan-cadmium-telluride quantum dot biosensor for detecting chronic myelogenous leukemia (CML). This electrochemical DNA sensor accurately identifies CML biomarkers in patient samples.

More Related Videos

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count
13:06

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count

Published on: July 11, 2012

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

Related Experiment Videos

Last Updated: May 21, 2026

Fluorescent Lateral Flow Immunoassay Based on Quantum Dots Nanobeads
07:13

Fluorescent Lateral Flow Immunoassay Based on Quantum Dots Nanobeads

Published on: June 28, 2024

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count
13:06

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count

Published on: July 11, 2012

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

Area of Science:

  • Nanomaterials Science
  • Biotechnology
  • Electrochemistry

Background:

  • Development of sensitive and specific diagnostic tools for early cancer detection is crucial.
  • Quantum dots offer unique optical and electronic properties for biosensing applications.
  • Chitosan is a biocompatible polymer suitable for nanomaterial functionalization.

Purpose of the Study:

  • To fabricate a novel electrochemical DNA biosensor using a chitosan-cadmium-telluride quantum dot (CS-CdTe-QDs) nanocomposite.
  • To evaluate the sensor's performance for detecting DNA sequences specific to chronic myelogenous leukemia (CML).
  • To assess the clinical applicability of the developed biosensor.

Main Methods:

  • Electrophoretic deposition of CS-CdTe-QDs nanocomposite onto an indium-tin-oxide (ITO) coated glass substrate.
  • Fabrication of an electrochemical DNA biosensor by immobilizing an amine-terminated oligonucleotide probe targeting the BCR-ABL fusion gene.
  • Characterization using high-resolution transmission electron microscopy (HR-TEM).
  • Performance evaluation using differential pulse voltammetry (DPV).

Main Results:

  • HR-TEM confirmed molecular-level coating of CdTe-QDs with CS.
  • The DNA biosensor demonstrated a low detection limit of 2.56 pM for complementary target DNA within 60 seconds.
  • The fabricated bioelectrode exhibited a shelf life of 6 weeks and reusability for 5-6 cycles.
  • The sensor successfully distinguished between CML-positive and CML-negative clinical patient samples.

Conclusions:

  • The CS-CdTe-QDs nanocomposite provides an effective platform for electrochemical DNA biosensor fabrication.
  • The developed biosensor shows high sensitivity, rapid response, and stability for CML detection.
  • This technology holds promise for the clinical diagnosis of chronic myelogenous leukemia.