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Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Published on: May 3, 2018

Association of changes in ambulatory arterial stiffness index and pulse wave velocity during antihypertensive

Yoshio Matsui1, Michael F O'Rourke, Joji Ishikawa

  • 1Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan. yoshio@jichi.ac.jp

American Journal of Hypertension
|June 1, 2012
PubMed

Insights

Arterial stiffness markers, ambulatory arterial stiffness index (AASI) and carotid-femoral pulse wave velocity (cfPWV), showed weak correlation during antihypertensive treatment. Neither AASI nor symmetrical AASI may be unequivocal markers of arterial stiffness.

Area of Science:

  • Cardiology
  • Hypertension Management
  • Vascular Physiology

Background:

  • Arterial stiffness is a key indicator of cardiovascular risk.
  • Ambulatory arterial stiffness index (AASI) is a potential non-invasive marker.
  • Carotid-femoral pulse wave velocity (cfPWV) is a gold standard for arterial stiffness measurement.

Purpose of the Study:

  • To investigate the association between changes in AASI and cfPWV during antihypertensive therapy.
  • To evaluate the utility of AASI as a marker of arterial stiffness compared to cfPWV.

Main Methods:

  • 207 hypertensive patients received olmesartan, then randomized to hydrochlorothiazide (HCTZ) or azelnidipine for 24 weeks.
  • cfPWV and 24-h ambulatory blood pressure monitoring (ABPM) were assessed at baseline and 24 weeks.
  • AASI was calculated using standard and symmetric regression of DBP on SBP.

Main Results:

  • cfPWV decreased more significantly with azelnidipine than HCTZ.
  • Change in AASI showed no significant correlation with change in cfPWV (r=0.08, P=0.26).
  • Change in symmetrical AASI showed a significant but weak correlation with cfPWV (r=0.22, P<0.001), remaining significant after multivariable adjustment.

Conclusions:

  • Neither AASI nor symmetrical AASI may serve as unequivocal markers of arterial stiffness during antihypertensive treatment.
  • cfPWV remains a more reliable measure of arterial stiffness changes in this context.
Abstract

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