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Updated: May 21, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
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Incisional hernia recurrence through genomic profiling: a pilot study.

R Calaluce1, J W Davis, S L Bachman

  • 1Department of Surgery, The University of Missouri Health Sciences Center, University of Missouri, One Hospital Drive, M610C, Columbia, MO 65212, USA. calalucer@health.missouri.edu

Hernia : the Journal of Hernias and Abdominal Wall Surgery
|June 1, 2012
PubMed
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Gene expression profiles differ between patients with recurrent incisional hernias and healthy controls. GREMLIN1, a bone morphogenetic protein antagonist, was underexpressed in recurrent incisional hernia patients, suggesting its role in hernia formation.

Area of Science:

  • Genetics and Molecular Biology
  • Surgical Research
  • Biomarkers

Background:

  • Incisional hernia formation is a common surgical complication.
  • Current methods for predicting susceptibility to incisional hernias are unreliable.
  • Recurrent incisional hernias may be associated with unique genetic factors.

Purpose of the Study:

  • To investigate gene expression profiles in patients with recurrent incisional hernias (RH) compared to normal controls (NC).
  • To identify potential genetic markers for incisional hernia susceptibility.
  • To explore the role of GREMLIN1 in incisional hernia formation.

Main Methods:

  • Skin and fascia samples were collected from RH and NC patients.
  • Whole genome microarray analysis was performed on a subset of samples.

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  • Pathway-specific PCR arrays were used to analyze fibrosis-related genes.

    • Main Results:

    • Distinct gene expression profiles were observed between RH and NC patients.
    • 167 skin genes and 7 fascia genes were differentially expressed.
    • GREMLIN1 was significantly underexpressed in both skin and fascia of RH patients.
    • Decreased collagen I/III ratios were observed in the skin of RH patients.

    Conclusions:

    • This is the first microarray-based study to demonstrate distinct gene expression profiles in the skin and fascia of RH and NC patients.
    • GREMLIN1 is identified as a potential factor associated with incisional hernia formation.
    • Gene expression profiles may serve as biomarkers to identify patients at risk for incisional hernias.